磷酸化HER3受体抗体Anti-Phospho-HER3 （Tyr1197）EGFR（Phospho-Tyr1197）; ERBB3; c erbB 3; c erbB3; ERBB3 protein; erbB3 S; Glial growth fact
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性能参数：

中文名称：磷酸化HER3受体抗体
英文名称：Anti-Phospho-HER3 （Tyr1197）
别名：EGFR（Phospho-Tyr1197）; ERBB3; c erbB 3; c erbB3; ERBB3 protein; erbB3 S; Glial growth fact
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：ErbB3 is a member of the epidermal growth factor receptor （EGFR） family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder ａnd breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. Isoform 2 lacks the intermembrane region ａnd is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized. Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 （LCCS2）; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord.

磷酸化HER3受体抗体的质量标准：

■其它名称：	EGFR（Phospho-Tyr1197）; ERBB3; c erbB 3; c erbB3; ERBB3 protein; erbB3 S; Glial growth fact
■交叉反应：	hu, rat, mo
■产品类型：	一抗磷酸化抗体
■应用领域:	/肿瘤/免疫学/信号转导/生长因子和激素/转录调节因子/激酶和磷酸酶/细胞类型标志物
■蛋白分子：	predicted molecular weight: 148kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human HER3 around the phosphorylation site of Tyr1197
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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由于化学产品的特殊性，恕不接受以下投诉：
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磷酸化HER3受体抗体Anti-Phospho-HER3 （Tyr1197）的相关产品目录：







1mg/1ml 磷酸化HER3受体抗体 Anti-Phospho-HER3 （Tyr1197） EGFR（Phospho-Tyr1197）; ERBB3; c erbB 3; c erbB3; ERBB3 protein; erbB3 S; Glial growth fact的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

查询其它抗体目录请点击本公司化工仪器网链接：http://www.chem17.com/st233816/erlist_675408.html

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