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谷胱甘肽过氧化酶4抗体 田源一抗
点击次数:175发布时间:2012/8/3 17:50:35
更新日期:2013/3/22 10:30:16
所 在 地:其它
产品型号:Anti-GPX4
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详细内容
谷胱甘肽过氧化酶4抗体Anti-GPX4Glutathione Peroxidase 4; Phospholipid hydroperoxide glutathione peroxidase; GPX 4; GPX4;
360TIYO.COM-上海田源公司
性能参数:
中文名称:谷胱甘肽过氧化酶4抗体
英文名称:Anti-GPX4
别名:Glutathione Peroxidase 4; Phospholipid hydroperoxide glutathione peroxidase; GPX 4; GPX4;
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site.Subcellular Location : Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm.Tissue Specificity : Present primarily in testis.Similarity : Belongs to the glutathione peroxidase family.Subunit : Monomer. Has a tendency to form higher mass oligomers.谷胱甘肽过氧化物酶(GSH-Px)是机体内广泛存在的一种重要的过氧化物分解酶。硒是GSH-Px酶系的组成成分,它能催化GSH变为GSSG,使有毒的过氧化物还原成无毒的羟基化合物,同时促进H2O2的分解,从而保护细胞膜的结构及功能不受过氧化物的干扰及损害。GSH-Px的活性中心是硒半胱氨酸,其活力大小可以反映机体硒水平。GSH-Px酶系主要包括4种不同的GSH-Px,分别为胞浆GSH-Px、血浆GSH-Px、磷脂氢过氧化物GSH-Px及胃肠道专属性GSH-Px。胞浆GSH-Px由4个相同的分子量大小为22kDa的亚基构成四聚体,每个亚基含有1个分子硒半胱氨酸,广泛存在于机体内各个组织,以肝脏红细胞为*多。它的生理功能主要是催化GSH参与过氧化反应,清除在细胞呼吸代谢过程中产生的过氧化物和羟自由基,从而减轻细胞膜多不饱和脂肪酸的过氧化作用。谷胱甘肽过氧化酶4抗体的质量标准:
■其它名称: | Glutathione Peroxidase 4; Phospholipid hydroperoxide glutathione peroxidase; GPX 4; GPX4; |
■交叉反应: | hu, mo, rat, cow, pig |
■产品类型: | 一抗 |
■应用领域: | /肿瘤/心血管/细胞生物/免疫学 |
■蛋白分子: | predicted molecular weight: 22kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human Glutathione Peroxidase 4 (140-185aa) |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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谷胱甘肽过氧化酶4抗体Anti-GPX4的相关产品目录:
1mg/1ml 谷胱甘肽过氧化酶4抗体 Anti-GPX4 Glutathione Peroxidase 4; Phospholipid hydroperoxide glutathione peroxidase; GPX 4; GPX4; 的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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