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干扰素/维甲酸诱导凋亡相关基因抗体 田源一抗
点击次数:158发布时间:2012/8/3 17:51:22
更新日期:2013/3/22 10:28:32
所 在 地:其它
产品型号:Anti-GRIM19
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详细内容
干扰素/维甲酸诱导凋亡相关基因抗体Anti-GRIM19CDA016; Cell death regulatory protein; Cell death regulatory protein GRIM-19; CGI-39; CGI3
360TIYO.COM-上海田源公司
性能参数:
中文名称:干扰素/维甲酸诱导凋亡相关基因抗体
英文名称:Anti-GRIM19
别名:CDA016; Cell death regulatory protein; Cell death regulatory protein GRIM-19; CGI-39; CGI3
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:A novel gene, Genes associated with Retinoid IFN induced Mortality (GRIM) GRIM19 gene was identified. Antisense expression of GRIM19 confers a strong resistance against IFN/RA induced death by reducing the intracellular levels of GRIM19 protein. Overexpression of GRIM19 enhances cell death in response to IFN/RA. GRIM19 is primarily a nuclear protein whose expression is induced by the IFN/RA combination. These data indicate that GRIM19 is a novel cell death regulatory molecule.GRIM19是GRIMs凋亡相关基因新家族成员,是一种由IFN-β联合RA(干扰素/维甲酸)诱导表达的16kDa蛋白,分布在细胞核和胞浆中,GRIM-19是纯化的线粒体呼吸链复合体I的组成成分,这种复合物为ATP合成所必需的,当线粒体复合物I电子转移产生活性,GRIM-19突变体突破线粒体跨膜电位,可增强细胞对凋亡刺激的敏感性,它的过高表达可以抑制肿瘤细胞的增殖,促进细胞的凋亡。干扰素/维甲酸诱导凋亡相关基因抗体的质量标准:
■其它名称: | CDA016; Cell death regulatory protein; Cell death regulatory protein GRIM-19; CGI-39; CGI3 |
■交叉反应: | hu, rat, mo |
■产品类型: | 一抗 |
■应用领域: | /肿瘤/细胞生物/免疫学/信号转导/细胞凋亡/转录调节因子 |
■蛋白分子: | predicted molecular weight: 16kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human GRIM19 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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干扰素/维甲酸诱导凋亡相关基因抗体Anti-GRIM19的相关产品目录:
1mg/1ml 干扰素/维甲酸诱导凋亡相关基因抗体 Anti-GRIM19 CDA016; Cell death regulatory protein; Cell death regulatory protein GRIM-19; CGI-39; CGI3的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
查询其它抗体目录请点击本公司化工仪器网链接:http://www.chem17.com/st233816/erlist_675408.html
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