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G蛋白偶联受体30抗体 田源一抗
点击次数:161发布时间:2012/8/3 17:56:14
更新日期:2013/3/22 10:20:50
所 在 地:其它
产品型号:Anti-GPR30
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详细内容
G蛋白偶联受体30抗体Anti-GPR30G Protein Coupled Receptor 30; G-protein coupled estrogen receptor 1; Membrane estrogen re
360TIYO.COM-上海田源公司
性能参数:
中文名称:G蛋白偶联受体30抗体
英文名称:Anti-GPR30
别名:G Protein Coupled Receptor 30; G-protein coupled estrogen receptor 1; Membrane estrogen re
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:G protein-coupled receptors (GPRs, or GPCRs) contain 7 hydrophobic transmembrane domains embedded in hydrophilic intra- and extracellular loops and transduce a variety of hormone, endogenous peptide, and neurotransmitter signals into intracellular effects via G proteins. GRP30 is a member of this family and is an orphan receptor. GPR30 expression has been reported in brain, breast carcinoma, blood, bone marrow, CNS, heart, liver, lung, lymph node, placenta, and spleen. In brain, GPR30 is expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen. However, unlike other known G protein-coupled receptors, GPR30 localizes to the endoplasmic reticulum, where it specifically binds estrogen and estrogen derivatives.Subcellular Location : Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.Tissue Specificity : In the paraventricular and supraoptic nuclei of the hypothalamus, expressed in magnocellular neurosecretory cells (MNCs) which secrete oxytocin but not in MNCs which secrete vasopressin (at protein level). Highly expressed in brain and lung, lower expression in heart, skeletal muscle and kidney.Similarity : Belongs to the G-protein coupled receptor 1 family. GPR30是一种膜性雌激素蛋白受体又称非基因型雌激素膜性受体GPR30。GPR30受体广泛表达于海马、下丘脑、子宫、卵巢、乳腺、骨和心血管等全身多个系统、器官和组织,在细胞内主要定位于细胞膜、内质网、线粒体和高尔基体。GPER与雌激素结合, ERK、PI3K/AKT)、 cAMP等第二信使途径发挥快速非基因效应,在神经系统、生殖系统、运动系统和心血管系统中发挥重要的生理作用。G蛋白偶联受体30抗体的质量标准:
■其它名称: | G Protein Coupled Receptor 30; G-protein coupled estrogen receptor 1; Membrane estrogen re |
■交叉反应: | hu, mo, rat, Rb, chk, hrs, cow |
■产品类型: | 一抗 |
■应用领域: | /细胞膜受体 |
■蛋白分子: | predicted molecular weight: 42kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human GPR30 C-terminus |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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G蛋白偶联受体30抗体Anti-GPR30的相关产品目录:
1mg/1ml G蛋白偶联受体30抗体 Anti-GPR30 G Protein Coupled Receptor 30; G-protein coupled estrogen receptor 1; Membrane estrogen re的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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