HER3受体抗体Anti-HER3/ErbB3c erbB 3; c erbB3; ERBB3; ERBB3 protein; erbB3 S; Glial growth factor receptor; HER 3; HER
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性能参数：

中文名称：HER3受体抗体
英文名称：Anti-HER3/ErbB3
别名：c erbB 3; c erbB3; ERBB3; ERBB3 protein; erbB3 S; Glial growth factor receptor; HER 3; HER
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：ErbB3 is a member of the epidermal growth factor receptor （EGFR） family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder ａnd breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. Isoform 2 lacks the intermembrane region ａnd is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized. Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 （LCCS2）; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord.Subcellular Location : soform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.Tissue Specificity : Epithelial tissues ａnd brain.Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.Contains 1 protein kinase domain.Subunit : Monomer ａnd homodimer. Heterodimer with each of the other ERBB receptors （Potential）. Interacts with CSPG5, PA2G4, GRB7 ａnd MUC1.

HER3受体抗体的质量标准：

■其它名称：	c erbB 3; c erbB3; ERBB3; ERBB3 protein; erbB3 S; Glial growth factor receptor; HER 3; HER
■交叉反应：	hu, mo, rat, Rb, hrs, Gpig, dog
■产品类型：	一抗
■应用领域:	/肿瘤/信号转导/生长因子和激素
■蛋白分子：	predicted molecular weight: 148kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human HER3
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//Flow-Cyt=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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友情提醒：
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
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HER3受体抗体Anti-HER3/ErbB3的相关产品目录：







1mg/1ml HER3受体抗体 Anti-HER3/ErbB3 c erbB 3; c erbB3; ERBB3; ERBB3 protein; erbB3 S; Glial growth factor receptor; HER 3; HER的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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