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热休克蛋白-60抗体 田源一抗
点击次数:190发布时间:2012/8/4 23:38:26
更新日期:2013/5/3 14:33:05
所 在 地:其它
产品型号:Anti-HSP60
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详细内容
热休克蛋白-60抗体Anti-HSP60HSP 60; HSP-60; 60 kDa chaperonin;60 kDa heat shock protein mitochondrial; 60kDa; cb863; C
360TIYO.COM-上海田源公司
性能参数:
中文名称:热休克蛋白-60抗体
英文名称:Anti-HSP60
别名:HSP 60; HSP-60; 60 kDa chaperonin;60 kDa heat shock protein mitochondrial; 60kDa; cb863; C
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Two pseudogenes, both located on chromosome 8, have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.信号传导(Signaling Intermediates) HSP60是一类进化上高度保守的蛋白质家族.生理状态时协助多肽或蛋白质的正确转位、折叠和装配,起"分子伴侣"的作用;在应激状态下,HSP60过表达或异位表达,作为一种自身抗原被免疫系统识别,诱发机体的保护性免疫应答,也可作为一种信号分子,在信号转导中发挥作用. 该蛋白与肿瘤的发生、增殖及分化有关,主要用于舌鳞癌、结肠癌、胰腺癌和乳腺癌的研究,近年来研究证实HSP60在自身免疫性疾病、传染病、动脉粥样硬化及慢性感染的发病中均发挥重要的作用。HSP-60热休克蛋白-蛋白质折叠过程的引导因子分子伴侣是一种引导蛋白质正确折叠的蛋白质。当蛋白质折叠时,它们能保护蛋白质分子免受其它蛋白质的干扰。很多分子伴侣属于热休克蛋白(例如HSP-60),它们在细胞受热时大量合成。热激可导致蛋白质稳定性降低,增加错误折叠的几率,因此在受到热刺激时,细胞中的蛋白质需要更多热休克蛋白的帮助。HSP-60是一种典型的分子伴侣,它可以为正在折叠的蛋白质提供一个附着环境,从而起到保护折叠过程的作用。热休克蛋白-60抗体的质量标准:
■其它名称: | HSP 60; HSP-60; 60 kDa chaperonin;60 kDa heat shock protein mitochondrial; 60kDa; cb863; C |
■交叉反应: | hu, rat, mo, dog, cow, hrs, Rb |
■产品类型: | 一抗 |
■应用领域: | /肿瘤/免疫学/信号转导/转录调节因子 |
■蛋白分子: | predicted molecular weight: 60kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human HSP60 C-terminus |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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热休克蛋白-60抗体Anti-HSP60的相关产品目录:
1mg/1ml 热休克蛋白-60抗体 Anti-HSP60 HSP 60; HSP-60; 60 kDa chaperonin;60 kDa heat shock protein mitochondrial; 60kDa; cb863; C的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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