端粒酶反转录酶抗体Anti-TRT/TERTTelomerase catalytic subunit; EST2; hEST2; TCS1; Telomerase associated protein 2; Telomere
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性能参数：

中文名称：端粒酶反转录酶抗体
英文名称：Anti-TRT/TERT
别名：Telomerase catalytic subunit; EST2; hEST2; TCS1; Telomerase associated protein 2; Telomere
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Telomeres are nucleoprotein structures at the ends of eukaryotic chromosomes. They regulate several crucial cellular functions ａnd participate in the control of complex phenotypes, such as aging ａnd cancer. Cell immortalization is strongly associated with the stabilization of telomere length. Therefore, it is suggested that cancer cells achieve immortalization in part through illegitimate activation of telomerase expression. Human telomerase reverse transcriptase （hTERT） is the rate limiting catalytic subunit of telomerase. It is also responsible for addition of TTAGGG repeats to the telomere ends of the chromosome, which is important in maintaining cell immortality. In most normal human cells the expression of hTERT is very low. On the other hand, greater than 90 % of human tumors of different pathology ａnd origins have been shown to upregulate telomerase expression, making hTERT a cancer associated target.Subcellular Location : Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Chromosome, telomere. Cytoplasm. Nucleus, PML body.Tissue Specificity : Expressed at a high level in thymocyte subpopulations, at an intermediate level in tonsil T-lymphocytes, ａnd at a low to undetectable level in peripheral blood T-lymphocytes.Similarity : Belongs to the reverse transcriptase family. Telomerase subfamily.Contains 1 reverse transcriptase domain.端粒酶是一种依赖RNA的DNA聚合酶,催化合成端粒体的DNA重复序列,并引导端粒添加到染色体的尾端,对维持染色体的长度、调节细胞增殖和凋亡起重要作用。端粒酶主要存在于恶性肿瘤之中，一般在大多数正常组织中没有活性或活性极低，同时由于端粒酶在恶性肿瘤的发展中起着关键作用，所以通过各种途径抑制端粒酶的活性可能地抑制大多数肿瘤的生长，而对大多数正常细胞没有影响。这种抑制作用可以通过直接抑制端粒酶活性、抑制端粒酶RNA或端粒酶蛋白成分以及诱导肿瘤细胞发生分化等方法实现。 端粒酶与恶性肿瘤之间令人惊异的相关性使它在肿瘤的诊断和治疗上有望成为行之的新的靶目标。

端粒酶反转录酶抗体的质量标准：

■其它名称：	Telomerase catalytic subunit; EST2; hEST2; TCS1; Telomerase associated protein 2; Telomere
■交叉反应：	hu, mo, rat
■产品类型：	一抗
■应用领域:	/肿瘤/细胞生物/免疫学/神经生物学/信号转导/细胞凋亡/细胞周期蛋白/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 125kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human TRT C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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由于化学产品的特殊性，恕不接受以下投诉：
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端粒酶反转录酶抗体Anti-TRT/TERT的相关产品目录：







1mg/1ml 端粒酶反转录酶抗体 Anti-TRT/TERT Telomerase catalytic subunit; EST2; hEST2; TCS1; Telomerase associated protein 2; Telomere的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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