羟类固醇脱氢酶17β抗体Anti-HSD17B111β-HSD1; 17 beta HSD 1; 17 beta hydroxysteroid dehydrogenase type 1; 17β-hydroxysteroid d
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性能参数：

中文名称：羟类固醇脱氢酶17β抗体
英文名称：Anti-HSD17B1
别名：11β-HSD1; 17 beta HSD 1; 17 beta hydroxysteroid dehydrogenase type 1; 17β-hydroxysteroid d
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：The principal human estrogen, 17 beta-estradiol, is a potent stimulator of certain endocrine-dependent forms of breast cancer. Because human estrogenic 17 beta-hydroxysteroid dehydrogenase （HSD17B1） catalyzes the last step in the biosynthesis of 17 beta-estradiol from the less potent estrogen, estrone, it is an attractive target for the design of inhibitors of estrogen production ａnd tumor growth. It is concluded that the steroid-binding site of human placental HSD17B1 contains a histidine residue which proximates the upper A-ring region of the steroid as it undergoes the reversible binding step. Human estrogenic HSD17B1 is an NADP（H）-preferring enzyme. It possesses 11- ａnd 4-fold higher specificity toward NADP（H） over NAD（H） for oxidation ａnd reduction, respectively, as demonstrated by kinetic studies. Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme HSD17B1 give rise to genetic males with female external genitalia.Subcellular Location : Cytoplasm.Similarity : Belongs to the short-chain dehydrogenases/reductases （SDR） family.Subunit : Homodimer.Ⅰ型17β-羟类固醇脱氢酶又称Ⅰ型17HSD，催化雌酮与雌二醇之间的转化，为性激素合成过程中步骤的催化酶。它催化性激素Ｃ17位上的酮基和醇基之间的还原和氧化反应 ,使低生物活性的雌酮、雄烯二酮与高生物活性的雌二醇、睾酮之间相互转化。17βHSD的结构和功能的异常与一些疾病 ,如肿瘤、假两性等的发生有密切关系.

羟类固醇脱氢酶17β抗体的质量标准：

■其它名称：	11β-HSD1; 17 beta HSD 1; 17 beta hydroxysteroid dehydrogenase type 1; 17β-hydroxysteroid d
■交叉反应：	hu, mo, rat, cow, hrs, dog, pig, Rb
■产品类型：	一抗
■应用领域:	/肿瘤/免疫学/生长因子和激素/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 35kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human HSD17B1 C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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羟类固醇脱氢酶17β抗体Anti-HSD17B1的相关产品目录：







1mg/1ml 羟类固醇脱氢酶17β抗体 Anti-HSD17B1 11β-HSD1; 17 beta HSD 1; 17 beta hydroxysteroid dehydrogenase type 1; 17β-hydroxysteroid d的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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