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整合素αVβ3抗体 田源一抗
点击次数:397发布时间:2012/8/5 0:17:11
更新日期:2013/6/8 9:48:40
所 在 地:其它
产品型号:Anti-Integrin Alpha V + Beta 3 (CD51+CD61)
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详细内容
整合素αVβ3抗体Anti-Integrin Alpha V + Beta 3 (CD51+CD61)CD51+CD61; CD51; CD61; GP3A; GPIIIa; integrin alpha v; integrin beta 3; intregrin alpha v
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中文名称:整合素αVβ3抗体
英文名称:Anti-Integrin Alpha V + Beta 3 (CD51+CD61)
别名:CD51+CD61; CD51; CD61; GP3A; GPIIIa; integrin alpha v; integrin beta 3; intregrin alpha v
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. They are known to participate in cell adhesion as well as cell-surface mediated signalling. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD51 encodes integrin alpha chain V. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. The CD61 protein product is the integrin beta chain beta 3. Integrin beta 3 is found along with the alpha IIb chain in platelets.Integrin alpha V/beta 3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha V/beta 3 recognizes the sequence R-G-D in a wide array of ligands. The alpha V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands.整合素αVβ3为二聚体的跨膜糖蛋白质,可以调节肿瘤细胞在多种细胞外基质蛋白中的粘附和迁移,在被激活的内皮细胞中有较高的表达,并在新生血管生成过程中发挥优势。整合素αVβ3在细胞外的信号传入细胞内调节细胞生长、改变细胞形态、影响细胞运动, 并在肿瘤侵袭和转移的过程中起重要作用.整合素αVβ3是特异性表达在血管内皮细胞表面的粘附因子。整合素αVβ3抗体的质量标准:
■其它名称: | CD51+CD61; CD51; CD61; GP3A; GPIIIa; integrin alpha v; integrin beta 3; intregrin alpha v |
■交叉反应: | hu, mo, rat |
■产品类型: | 一抗 |
■应用领域: | /细胞生物/免疫学/信号转导/干细胞/细胞粘附分子 |
■蛋白分子: | |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human Integrin Alpha V + Beta 3 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //ELISA=1:500-1000//IHC-P=1:100-500//IHC-F=1:100-500//Flow-Cyt=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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整合素αVβ3抗体Anti-Integrin Alpha V + Beta 3 (CD51+CD61)的相关产品目录:
1mg/1ml 整合素αVβ3抗体 Anti-Integrin Alpha V + Beta 3 (CD51+CD61) CD51+CD61; CD51; CD61; GP3A; GPIIIa; integrin alpha v; integrin beta 3; intregrin alpha v 的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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