硫酸乙酰肝素蛋白多糖2Anti-Perlecan/Heparan Sulfate Proteoglycan 2Basement membrane specific heparan sulfate proteoglycan core protein; Endorepellin （domain
360TIYO.COM-上海田源公司

性能参数：

中文名称：硫酸乙酰肝素蛋白多糖2
英文名称：Anti-Perlecan/Heparan Sulfate Proteoglycan 2
别名：Basement membrane specific heparan sulfate proteoglycan core protein; Endorepellin （domain
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－

产品详细描述

产品介绍：This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans（heparan sulfate or chondroitin sulfate） are attached. The perlecan protein is a large multidomain proteoglycan that binds to ａnd cross-links many extracellular matrix components ａnd cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 ａnd Transthyretin, etc. ａnd plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation ａnd is thus thought to help maintain vascular homeostasis. It can also promote growth factor （e.g., FGF2） activity ａnd thus stimulate endothelial growth ａnd re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules ａnd cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, ａnd Tardive dyskinesia.[provided by RefSeq, Mar 2010].Subcellular Location : Secreted, extracellular space, extracellular matrix, basement membrane.Tissue Specificity : Found in the basement membranes.Similarity : Contains 4 EGF-like domains. Contains 22 Ig-like C2-type （immunoglobulin-like） domains. Contains 11 laminin EGF-like domains. Contains 3 laminin G-like domains. Contains 3 laminin IV type A domains. Contains 4 LDL-receptor class A domains. Contains 1 SEA domain.[FUNCTION] Integral component of basement membranes. Component of the glomerular basement membrane （GBM）, responsible for the fixed negative electrostatic membrane charge, ａnd which provides a barrier which is both size- ａnd charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development ａnd for regulating the vascular response to injury. Also required for avascular cartilage development.[FUNCTION] Endorepellin in an anti-angiogenic ａnd anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis ａnd blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin ａnd type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.[FUNCTION] The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.

硫酸乙酰肝素蛋白多糖2的质量标准：

■其它名称：	Basement membrane specific heparan sulfate proteoglycan core protein; Endorepellin （domain
■交叉反应：	hu, mo, rat, pig, hrs, cow
■产品类型：	一抗
■应用领域:	/肿瘤/免疫学/转录调节因子/糖蛋白
■蛋白分子：	predicted molecular weight: 469kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human Heparan Sulfate Proteoglycan 2
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－

质量投诉流程
1、向我们的客户服务部反应投诉原因及订单信息。
2、向我们发送投诉相关的证明材料。
3、田源时间进行质量投诉调查及处理调查结果。
4、田源将联系客户并提供质量投诉处理结果。

友情提醒：
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
1、超过质量投诉期的进口产品投诉
2、非质量报告提及的指标投诉

硫酸乙酰肝素蛋白多糖2Anti-Perlecan/Heparan Sulfate Proteoglycan 2的相关产品目录：







1mg/1ml 硫酸乙酰肝素蛋白多糖2 Anti-Perlecan/Heparan Sulfate Proteoglycan 2 Basement membrane specific heparan sulfate proteoglycan core protein; Endorepellin （domain的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

查询其它抗体目录请点击本公司化工仪器网链接：http://www.chem17.com/st233816/erlist_675408.html

上海田源专业销售硫酸乙酰肝素蛋白多糖2 Anti-Perlecan/Heparan Sulfate Proteoglycan 2，了解更多请点击查询！