羟基类固醇脱氢酶11β2抗体Anti-HSD11B2Corticosteroid 11 beta dehydrogenase isozyme 2; 11 beta HSD2; 11 beta hydroxysteroid dehyd
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性能参数：

中文名称：羟基类固醇脱氢酶11β2抗体
英文名称：Anti-HSD11B2
别名：Corticosteroid 11 beta dehydrogenase isozyme 2; 11 beta HSD2; 11 beta hydroxysteroid dehyd
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：HSD11B2 catalyzes the conversion of cortisol to the inactive metabolite cortisone. The protein modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.Defects in HSD11B2 are the cause of apparent mineralocorticoid excess （AME）. AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia ａnd low levels of aldosterone. It often leads to nephrocalcinosis.Subcellular Location : Microsome. Endoplasmic reticulum.Tissue Specificity : Found in placenta, kidney, pancreas, prostate, ovary, small intestine ａnd colon.Similarity : Belongs to the short-chain dehydrogenases/reductases （SDR） family.Subunit : Interacts with ligand-free cytoplasmic NR3C2.[DISEASE] Defects in HSD11B2 are the cause of apparent mineralocorticoid excess （AME） [MIM:218030]. An autosomal recessive form of low-renin hypertension. It is usually diagnosed within the first years of life ａnd is characterized by polyuria ａnd polydipsia, failure to thrive, hypernatremia, severe hypertension with low renin ａnd aldosterone levels, profound hypokalemia with metabolic alkalosis, ａnd most often nephrocalcinosis.

羟基类固醇脱氢酶11β2抗体的质量标准：

■其它名称：	Corticosteroid 11 beta dehydrogenase isozyme 2; 11 beta HSD2; 11 beta hydroxysteroid dehyd
■交叉反应：	hu, mo, rat, dog, hrs
■产品类型：	一抗
■应用领域:	/肿瘤/免疫学/信号转导/细胞凋亡/转录调节因子/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 45kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human HSD11B2
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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羟基类固醇脱氢酶11β2抗体Anti-HSD11B2的相关产品目录：







1mg/1ml 羟基类固醇脱氢酶11β2抗体 Anti-HSD11B2 Corticosteroid 11 beta dehydrogenase isozyme 2; 11 beta HSD2; 11 beta hydroxysteroid dehyd的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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