胰岛素受体β抗体Anti-Insulin Receptor BetaCD 220; CD220; CD220 antigen; HHF 5; HHF5; INSR; INSRβ; Insulin Receptor β; IR.
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性能参数：

中文名称：胰岛素受体β抗体
英文名称：Anti-Insulin Receptor Beta
别名：CD 220; CD220; CD220 antigen; HHF 5; HHF5; INSR; INSRβ; Insulin Receptor β; IR.
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：The insulin receptor is a heterotetrameric membrane glycoprotein with tyrosine-protein kinase activity, consisting of disulfide-linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit possesses a single transmembrane domain, whereas the alpha subunit is completely extracellular. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Binding of insulin to the insulin receptor stimulates its association with downstream mediators including IRS1 ａnd phosphatidylinositol 3＇-kinase （PI3K） which leads to glucose uptake. Two transcript variants encoding different isoforms have been found for this gene produced by alternative splicing.Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement ａnd cell movement, apoptosis, ａnd differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine （PTK） or serine/threonine （STK） kinase catalytic domains. The tyrosine kinase （TK） group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility ａnd death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK （e.g. EGFR, EPH, FGFR, PDGFR, TRK, ａnd VEGFR families）, ａnd 32 of cytosolic TK （e.g. ABL, FAK, JAK, ａnd SRC families）. 胰岛素受体是一个四聚体，由两个α亚基和两个β亚基通过二硫键连接。两个α亚基位于细胞质膜的外侧，其上有胰岛素的结合位点；两个β亚基是跨膜蛋白，起信号转导作用。无胰岛素结 合时，受体的酪氨酸蛋白激酶没有活性。当胰岛素与受体的α亚基结合并改变了β亚基的构型后，酪氨酸蛋白激酶才被激活，激活后可催化两个反应：①使四聚体复合物中β亚基特异位点的酪氨酸残基磷酸化,这种过程称为自我磷酸化（autophosphorylation）；②将胰岛素受体底物（insulin receptor substrate，IRSs）上具有重要作用的十几个酪氨酸残基磷酸化，磷酸化的IRSs能够结合并激活下游效应物。

胰岛素受体β抗体的质量标准：

■其它名称：	CD 220; CD220; CD220 antigen; HHF 5; HHF5; INSR; INSRβ; Insulin Receptor β; IR.
■交叉反应：	hu, mo, rat
■产品类型：	一抗
■应用领域:	/神经生物学/信号转导/细胞凋亡/激酶和磷酸酶/糖尿病/内分泌病
■蛋白分子：	predicted molecular weight: 152kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human IR beta C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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胰岛素受体β抗体Anti-Insulin Receptor Beta的相关产品目录：







1mg/1ml 胰岛素受体β抗体 Anti-Insulin Receptor Beta CD 220; CD220; CD220 antigen; HHF 5; HHF5; INSR; INSRβ; Insulin Receptor β; IR. 的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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