核因子κB抑制蛋白α抗体Anti-NFKBIA/IKB alphaInhibitor of KB alpha; I kappa B alpha; I（Kappa）B（alpha）; IkappaBalpha; IKBA; IKBalpha; MA
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性能参数：

中文名称：核因子κB抑制蛋白α抗体
英文名称：Anti-NFKBIA/IKB alpha
别名：Inhibitor of KB alpha; I kappa B alpha; I（Kappa）B（alpha）; IkappaBalpha; IKBA; IKBalpha; MA
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Three major forms of IKB like molecules have been identified ａnd each is characterised by multiple copies of ankyrin repeats. IKB alpha ａnd IKB beta appear to be the major regulatory forms of IKB in most cells. These proteins interact with p65 or cRel containing forms of NFkB ａnd block nuclear import by masking the nuclear localisation sequences of NFkB. The activation of NFkB involves the inducible phosphorylation ａnd subsequent degradation of IKB. Immunoblotting easily detects the hyperphosphorylated forms of IKB alpha, but not phosphorylated IKB beta. Interestingly, IKB alpha ａnd IKB beta mediate different NFkB responses. IkB alpha appears to control more transient activation of NFkB in response to an inducer, while IKB beta controls a persistent response. Bcl3 interacts with p50 ａnd p52 containing forms of NFkB, but rather than being an inhibitor it appears to function to stimulate transcription. The degradation of IKB is confirmed by immunoblotting.Subcellular Location : Cytoplasm. Nucleus.Tissue Specificity : Highly expressed in lymph node, thymus followed by liver, brain, muscle, kidney, gastrointestinal ａnd reproductive tract.Similarity : Belongs to the NF-kappa-B inhibitor family.Contains 5 ANK repeats.Subunit : Interacts with RELA; the interaction requires the nuclear import signal. Interacts with NKIRAS1 ａnd NKIRAS2. Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP ａnd MAP3K14. Interacts with HBV protein X. Interacts with RWDD3; the interaction enhances sumoylation. Interacts （when phosphorylated at the 2 serine residues in the destruction motif D-S-G-X（2,3,4）-S） with BTRC. Associates with the SCF（BTRC） complex, composed of SKP1, CUL1 ａnd BTRC; the association is mediated via interaction with BTRC. Part of a SCF（BTRC）-like complex lacking CUL1, which is associated with RELA; RELA interacts directly with NFKBIA. Interacts with PRMT2. Interacts with PRKACA in platelets; this interaction is disrupted by thrombin ａnd collagen. Interacts with HIF1AN.转录调节因子（Transcriptin Regulators）

核因子κB抑制蛋白α抗体的质量标准：

■其它名称：	Inhibitor of KB alpha; I kappa B alpha; I（Kappa）B（alpha）; IkappaBalpha; IKBA; IKBalpha; MA
■交叉反应：	hu, rat, mo
■产品类型：	一抗
■应用领域:	/肿瘤/免疫学/信号转导/转录调节因子/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 35kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human IKB alpha
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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核因子κB抑制蛋白α抗体Anti-NFKBIA/IKB alpha的相关产品目录：







1mg/1ml 核因子κB抑制蛋白α抗体 Anti-NFKBIA/IKB alpha Inhibitor of KB alpha; I kappa B alpha; I（Kappa）B（alpha）; IkappaBalpha; IKBA; IKBalpha; MA的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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