原癌基因K-ras抗体Anti-KRASC-K-RAS; c-Ki-ras; c-Ki-ras p21; Ha-ras; K-RAS B; K-RAS2A; K-RAS2B; K-RAS4A; KI-RAS; KI-RA
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性能参数：

中文名称：原癌基因K-ras抗体
英文名称：Anti-KRAS
别名：C-K-RAS; c-Ki-ras; c-Ki-ras p21; Ha-ras; K-RAS B; K-RAS2A; K-RAS2B; K-RAS4A; KI-RAS; KI-RA
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas ａnd colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq]Ras, a proto-oncogene, is a small G-protein that has 3 primary isoforms （H-Ras, N-Ras, ａnd K-Ras） that differ in there approximately 20 C-terminal amino acids. H-Ras was first discovered as a transforming product the retrovirus Harvey murine virus ａnd K-Ras of Kirten sarcoma virus. Ras is a heavily studied target of both academic ａnd pharmaceutical research because of its implications in various pathways ａnd diseases as well as being mutated in a large number of human cancers. Ras is most notably the activator of the Erk/MAPK kinase pathway as activator of Raf, as well as an activator of PI3 Kinase （PI3K）. In its oncogenic, mutated state, Ras is unable to hydrolyze GTP to GDP, thus staying in an active state ａnd activating numerous pathways including the MAPK pathway through its activation of Raf, but also others as well that include PI3 Kinase ａnd RalGDS. One path that the pharmaceutical industry has taken to control Ras ａnd its activity is by finding what some consider its Achilles’ heel. For its activation, Ras must localize to the plasma membrane, but interestingly, it lacks a transmembrane domain. To achieve this, Ras must first undergo a post-translational modification （PTM） known as prenylation or geranylation at its C-terminal CAAX motif. For this to take place, a controlled three step process must occur. The first step in the process is the prenylation or geranylation of the C in the CAAX motif that is initiated by the covalent attachment of farnesyl groups to the cysteine that is catalyzed by the . After this modification, the ａnd heterodimer enzymes farnesyl transferases –aaX of the motif is proteolytically removed via Rce1 （Ras Converting Enzyme 1）, a membrane associated endoprotease, by a mechanism that is still not fully understood. Finally, the C-terminal prenylcysteine is now methlylated by ICMT （Isoprenylcysteine Carboxymethyl Transferase）. These drugs have yet to pass clinical trials though ａnd there is doubt that they will ever be successful in treating tumors associated with Ras activation.Subcellular Location : Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. Isoform 2: Nucleus. Cytoplasm. Cytoplasm, perinuclear region.Tissue Specificity : Widely expressed.Similarity : Belongs to the small GTPase superfamily. Ras family.Subunit : In its GTP-bound form interacts with PLCE1. Interacts with TBC1D10C. Interacts with RGL3. Interacts with HSPD1. Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3 ａnd RGS14. Interacts （active GTP-bound form） with RGS14 （via RBD 1 domain）. Forms a signaling complex with RASGRP1 ａnd DGKZ. Interacts with RASSF5. Interacts with PDE6D. Interacts with IKZF3. Interacts with GNB2L1.K-ras癌变基因的表达产物Ras蛋白存在于多数肿瘤之中，目前是肿瘤研究较重要的蛋白。

原癌基因K-ras抗体的质量标准：

■其它名称：	C-K-RAS; c-Ki-ras; c-Ki-ras p21; Ha-ras; K-RAS B; K-RAS2A; K-RAS2B; K-RAS4A; KI-RAS; KI-RA
■交叉反应：	hu, mo, rat
■产品类型：	一抗
■应用领域:	/肿瘤/细胞生物/免疫学/信号转导/细胞凋亡/细胞膜受体/转运蛋白
■蛋白分子：	predicted molecular weight: 21kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human K-ras N-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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1、向我们的客户服务部反应投诉原因及订单信息。
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友情提醒：
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
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原癌基因K-ras抗体Anti-KRAS的相关产品目录：







1mg/1ml 原癌基因K-ras抗体 Anti-KRAS C-K-RAS; c-Ki-ras; c-Ki-ras p21; Ha-ras; K-RAS B; K-RAS2A; K-RAS2B; K-RAS4A; KI-RAS; KI-RA的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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