磷酸化蛋白酪氨酸激酶JAK-3抗体Anti-Phospho-Jak3 （Tyr785）JAK 3; JAK L; JAK3 HUMAN; JAKL; Janus kinase 3 （a protein tyrosine kinase, leukocyte）; Jan
360TIYO.COM-上海田源公司

性能参数：

中文名称：磷酸化蛋白酪氨酸激酶JAK-3抗体
英文名称：Anti-Phospho-Jak3 （Tyr785）
别名：JAK 3; JAK L; JAK3 HUMAN; JAKL; Janus kinase 3 （a protein tyrosine kinase, leukocyte）; Jan
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate ａnd adaptive immunity ａnd plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R ａnd IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers ａnd translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 ａnd JAK3 molecules bind to IL2R beta （IL2RB） ａnd gamma chain （IL2RG） subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated ａnd activated by JAK1 ａnd JAK3. Once activated, dimerized STAT5 translocates to the nucleus ａnd promotes the transcription of specific target genes in a cytokine-specific fashion.

磷酸化蛋白酪氨酸激酶JAK-3抗体的质量标准：

■其它名称：	JAK 3; JAK L; JAK3 HUMAN; JAKL; Janus kinase 3 （a protein tyrosine kinase, leukocyte）; Jan
■交叉反应：	hu, mo, rat, dog, cow, pig, hrs
■产品类型：	一抗磷酸化抗体
■应用领域:	/肿瘤/免疫学/信号转导/转录调节因子/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 125kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human Jak3 around the phosphorylation site of Tyr785
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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由于化学产品的特殊性，恕不接受以下投诉：
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磷酸化蛋白酪氨酸激酶JAK-3抗体Anti-Phospho-Jak3 （Tyr785）的相关产品目录：







1mg/1ml 磷酸化蛋白酪氨酸激酶JAK-3抗体 Anti-Phospho-Jak3 （Tyr785） JAK 3; JAK L; JAK3 HUMAN; JAKL; Janus kinase 3 （a protein tyrosine kinase, leukocyte）; Jan的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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