磷酸化蛋白质酪氨酸激酶JAK-1抗体Anti-Phospho-Jak1 （Tyr1022/1023）JAK1（Phospho-Tyr1022）; JAK 1; JAK 1A; JAK 1B; JAK1; JAK1A; JAK1B; Janus kinase 1 （a protei
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性能参数：

中文名称：磷酸化蛋白质酪氨酸激酶JAK-1抗体
英文名称：Anti-Phospho-Jak1 （Tyr1022/1023）
别名：JAK1（Phospho-Tyr1022）; JAK 1; JAK 1A; JAK 1B; JAK1; JAK1A; JAK1B; Janus kinase 1 （a protei
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Janus kinase 1 （JAK1） is a member of a new class of non-receptor protein-tyrosine kinases （PTK） characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK ａnd threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta ａnd -gamma signal transduction pathways. The reciprocal interdependence between JAK1 ａnd TYK2 activities in the interferon-alpha pathway, ａnd between JAK1 ａnd JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins ａnd a unique family of transcription factors termed the signal transducers ａnd activators of transcription, or STATs.Subcellular Location : Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.Tissue Specificity : Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.Contains 1 FERM domain.Contains 1 protein kinase domain.Contains 1 SH2 domain.Subunit : Interacts with FER. Interacts with IL31RA, IFNAR2, JAKMIP1 ａnd SHB.

磷酸化蛋白质酪氨酸激酶JAK-1抗体的质量标准：

■其它名称：	JAK1（Phospho-Tyr1022）; JAK 1; JAK 1A; JAK 1B; JAK1; JAK1A; JAK1B; Janus kinase 1 （a protei
■交叉反应：	hu, mo, rat, cow, pig
■产品类型：	一抗磷酸化抗体
■应用领域:	/肿瘤/免疫学/神经生物学/信号转导/转录调节因子/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 127kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human Jak1 around the phosphorylation site of Tyr1022/1023
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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磷酸化蛋白质酪氨酸激酶JAK-1抗体Anti-Phospho-Jak1 （Tyr1022/1023）的相关产品目录：







1mg/1ml 磷酸化蛋白质酪氨酸激酶JAK-1抗体 Anti-Phospho-Jak1 （Tyr1022/1023） JAK1（Phospho-Tyr1022）; JAK 1; JAK 1A; JAK 1B; JAK1; JAK1A; JAK1B; Janus kinase 1 （a protei的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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