激肽释放酶14抗体Anti-KLK14Kallikrein 14; kallikrein-related peptidase 14; hK14; Kallikrein-like protein 6; KLK-L6; K
360TIYO.COM-上海田源公司

性能参数：

中文名称：激肽释放酶14抗体
英文名称：Anti-KLK14
别名：Kallikrein 14; kallikrein-related peptidase 14; hK14; Kallikrein-like protein 6; KLK-L6; K
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－

产品详细描述

产品介绍：The human tissue Kallikrein gene family encodes 15 serine proteases. All Kallikreins share structural similarities including cysteine residues, a catalytic triad of His, Asp ａnd Ser residues, typically five coding exons, ａnd varied intron phases. Kallikreins are predominantly secreted as inactive zymogens prior to activation by cleavage of an N-terminal peptide ａnd all function extracellularly. Kallikreins can be activated autocatalytically, via other Kallikreins, or additional proteases. While structurally similar, Kallikrein family members have distinct functions ａnd have key roles in many physiological ａnd pathological processes. Many human tissue Kallikreins also show promise as cancer biomarkers, which may facilitate earlier detection ａnd characterization of many forms of cancer. Kallikrein 14, also known as kallikrein-like6 （KLK-L6）, is a trypsin-like serine proteinase. Kallikrein 14 was discovered by cloning the kallikrein locus on chromosome 19 ａnd was found to be similar to the other kallikrein family genes. Kallikrein 14 is produced by a number of tissues, including the brain, spinal cord, esophagus, salivary gland, breast, prostate, uterus, lung, thymus ａnd thyroid. Like many of the kallikreins, Kallikrein 14 is also found in biological fluids like serum, breast milk, amniotic fluid, seminal plasma ａnd cerebrospinal fluid. Kallikrein 14 message has been reported to be decreased in some breast cancers ａnd in ovarian cancers, similar to Kallikrein 10. Some cell lines express Kallikrein 14 in culture ａnd like many of the kallikreins, the production is stimulated by hormones. Recombinant kallikrein 14 was profiled on peptide substrates ａnd found to possess both trypsin-like ａnd chymotrypsin-like activity. The ECM proteins lamanin ａnd collagen-IV are thought to be substrates of Kallikrein 14. Endogenous inhibitors include kallistatin, protein-C inhibitor ａnd alpha1-proteinase inhibitor, although Kallikrein 14 can be found complexed to a number of different proteinase inhibitors.Subcellular Location : Secreted, extracellular space.Tissue Specificity : "Highly expressed in CNS, bone marrow ａnd fetal liver. Similarity : Belongs to the Bcl-2 family.Subunit : Interacts directly with BAK1, BID, BMF ａnd BBC3 （By similarity）. Interacts directly with BCL2L11/BIM. Interacts with BAX isoform Sigma.KLK14目前认为在宫颈鳞癌和腺癌中都有表达,是很有意义的标志物。激肽释放酶KLK是激肽系统的主要限速酶，它是一组存在于多数组织和体液中的丝氨酸蛋白酶，是一种肽链内切酶。KLK又称血管舒缓素，包括15个家族成员。在不同的组织中广泛表达,具有蛋白水解酶的活性。它特异性的在碳末端切割底物肽，可裂解激肽原释放具有活性的激肽，由激肽发挥对心血管系统及肾脏功能的调节作用。

激肽释放酶14抗体的质量标准：

■其它名称：	Kallikrein 14; kallikrein-related peptidase 14; hK14; Kallikrein-like protein 6; KLK-L6; K
■交叉反应：	hu, mo, rat, cow, hrs, dog
■产品类型：	一抗
■应用领域:	/肿瘤/细胞生物/信号转导/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 25/29kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human KLK14 C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－

质量投诉流程
1、向我们的客户服务部反应投诉原因及订单信息。
2、向我们发送投诉相关的证明材料。
3、田源时间进行质量投诉调查及处理调查结果。
4、田源将联系客户并提供质量投诉处理结果。

友情提醒：
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
1、超过质量投诉期的进口产品投诉
2、非质量报告提及的指标投诉

激肽释放酶14抗体Anti-KLK14的相关产品目录：







1mg/1ml 激肽释放酶14抗体 Anti-KLK14 Kallikrein 14; kallikrein-related peptidase 14; hK14; Kallikrein-like protein 6; KLK-L6; K的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

查询其它抗体目录请点击本公司化工仪器网链接：http://www.chem17.com/st233816/erlist_675408.html

上海田源专业销售激肽释放酶14抗体 Anti-KLK14，了解更多请点击查询！