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钙结合蛋白39抗体 田源一抗
点击次数:171发布时间:2012/8/7 16:04:12
更新日期:2013/6/7 11:28:23
所 在 地:其它
产品型号:Anti-MO25 alpha/CAB39
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详细内容
钙结合蛋白39抗体Anti-MO25 alpha/CAB39CAB39; Calcium binding protein 39; CGI 66; CGI66; MO25 alpha; MO25; Mouse protein 25 alpha
360TIYO.COM-上海田源公司
性能参数:
中文名称:钙结合蛋白39抗体
英文名称:Anti-MO25 alpha/CAB39
别名:CAB39; Calcium binding protein 39; CGI 66; CGI66; MO25 alpha; MO25; Mouse protein 25 alpha
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Mouse protein 25 alpha (MO25 alpha, CAB39) is a 40-kDa protein that, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). CAB39 binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity. Skeletal muscle contraction results in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase (AMPKK). The LKB1-STE-related adaptor (STRAD)-mouse protein 25 (MO25) complex is the major AMPKK in skeletal muscle; however, LKB1-STRAD-MO25 activity is not increased by muscle contraction. This relationship suggests that phosphorylation of AMPK by LKB1-STRAD-MO25 during skeletal muscle contraction may be regulated by allosteric mechanisms.Subcellular Location : CytoplasmSimilarity : Belongs to the Mo25 family.Subunit : Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.钙结合蛋白39抗体的质量标准:
■其它名称: | CAB39; Calcium binding protein 39; CGI 66; CGI66; MO25 alpha; MO25; Mouse protein 25 alpha |
■交叉反应: | hu, mo, rat, hrs, pig, dog, chk, cow, Rb |
■产品类型: | 一抗 |
■应用领域: | /细胞生物/免疫学/信号转导/转录调节因子/激酶和磷酸酶 |
■蛋白分子: | predicted molecular weight: 38kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human MO25 alpha/CAB39 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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钙结合蛋白39抗体Anti-MO25 alpha/CAB39的相关产品目录:
1mg/1ml 钙结合蛋白39抗体 Anti-MO25 alpha/CAB39 CAB39; Calcium binding protein 39; CGI 66; CGI66; MO25 alpha; MO25; Mouse protein 25 alpha的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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