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LRIG1抗体 田源一抗
点击次数:101发布时间:2012/8/7 16:05:38
更新日期:2013/6/7 10:38:57
所 在 地:其它
产品型号:Anti-LRIG1
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详细内容
LRIG1抗体Anti-LRIG1leucine-rich repeat protein LRIG1; leucine rich repeats and immunoglobulin-like domains 1;
360TIYO.COM-上海田源公司
性能参数:
中文名称:LRIG1抗体
英文名称:Anti-LRIG1
别名:leucine-rich repeat protein LRIG1; leucine rich repeats and immunoglobulin-like domains 1;
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:LRIG1 protein is coded by a gene on a chromosome band 3p14.3, a region known to be deleted in various human cancers. It is considered to be a tumour suppressor gene. LRIG1 is an integral cell-surface membrane protein that is expressed by specific cells in various human tissues. Its 143kDa form may be cleaved into 111kDa and 32kDa fragments. The protein may inhibit the growth of tumors of glial cells and the down-regulation of the LRIG1 gene may be involved in the development and progression of the tumor.Subcellular Location : Membrane; Single-pass type I membrane protein.Tissue Specificity : Widely expressed.Similarity : Contains 3 Ig-like C2-type (immunoglobulin-like) domains.Contains 15 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain.Subunit : Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4.LRIG1属于LRIGs基因家族。LRIGs是新发现的一类基因,在哺乳动物体内广泛存在,目前发现该家族至少包括三个成员:LRIG1、LRIG2和LRIG3,是一类结构相似的跨膜糖蛋白,该蛋白人、鼠的同源性较高。 目前在肿瘤方面的研究较多,有研究认为:LRIG1是通过下调EGFR的表达来抑制其下游重要信号传导通路的激活而发挥抑癌作用,LRIG1在抑制肿瘤转移中具有重要作用。<LRIG1抗体的质量标准:
■其它名称: | leucine-rich repeat protein LRIG1; leucine rich repeats and immunoglobulin-like domains 1; |
■交叉反应: | hu, mo, rat |
■产品类型: | 一抗 |
■应用领域: | /肿瘤 |
■蛋白分子: | predicted molecular weight: 120kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human LRIG1 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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LRIG1抗体Anti-LRIG1的相关产品目录:
1mg/1ml LRIG1抗体 Anti-LRIG1 leucine-rich repeat protein LRIG1; leucine rich repeats and immunoglobulin-like domains 1;的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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