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瘦素受体抗体(长) 田源一抗
点击次数:199发布时间:2012/8/7 16:06:12
更新日期:2013/6/7 10:38:52
所 在 地:其它
产品型号:Anti-Leptin receptor(long)
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详细内容
瘦素受体抗体(长)Anti-Leptin receptor(long)obl; CD 295; CD295; CD295 antigen; Db; Fa; HuB219; LEP R; LEPR; LEPROT; Leptin receptor fa
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性能参数:
中文名称:瘦素受体抗体(长)
英文名称:Anti-Leptin receptor(long)
别名:obl; CD 295; CD295; CD295 antigen; Db; Fa; HuB219; LEP R; LEPR; LEPROT; Leptin receptor fa
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Leptin receptor (OB-R) is a type I cytokine receptor family protein with significant amino acid sequence identity with gp130, G-CSF receptor, and LIF receptor. An OB-R transcript encodes a soluble form of the receptor. The transcript was reported to be expressed predominantly in regions of the hypothalamus previously thought to be important in body weight regulation. OB-R binds leptin with high affinity and is a potent leptin antagonist. Human OB-R encodes a 1 165 amino acid residue precursor protein with a 22 amino acid residue signal peptide, an 816 amino acid residue extracellular domain, a 21 amino acid residue transmembrane domain and a 303 amino acid residue cytoplasmic domain.Subcellular Location : Cell membrane; Single-pass type I membrane protein. Isoform E: Secreted (Probable).Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.Tissue Specificity : Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.Similarity : Belongs to the type I cytokine receptor family. Type 2 subfamily.Contains 4 fibronectin type-III domains.Contains 1 Ig-like (immunoglobulin-like) domain.Subunit : On leptin stimulation, homodimerizes. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3. Interaction with SOCS3 inhibits LRb signaling.Leptin是一种分子量为16kDa的脂肪组织源激素,由脂肪细胞分泌的,具有强亲水性,以单体形式存在于血浆中。 Leptin 具有广泛的生物学效应,作用于下丘脑,调节食欲、能量代谢及体重。Leptin 还可能作为脂肪-胰岛内分泌轴一部分,参与胰岛素分泌的调节。Leptin receptor (OB-R)是与gp130*密切相关的信号转导的共同成分,属1类细胞因子超家族,下丘脑有丰富的Leptin receptor,在其它部位也有分布,但水平较低:如胰岛素B细胞;脉络丛;肝、肺、心、肾、睾丸、淋巴细胞和脂肪细胞中。 人类存在四个异性体,均为单跨膜受体。其中OB-Rb在胞内结构域*长,是能进行信号传导并调节热量摄入和能量消耗的异性体,分子量为132kDa。瘦素受体抗体(长)的质量标准:
■其它名称: | obl; CD 295; CD295; CD295 antigen; Db; Fa; HuB219; LEP R; LEPR; LEPROT; Leptin receptor fa |
■交叉反应: | hu, mo, rat, cow, dog, pig, shp |
■产品类型: | 一抗 |
■应用领域: | /心血管/神经生物学/信号转导/生长因子和激素/脂蛋白/新陈代谢 |
■蛋白分子: | predicted molecular weight: 132kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human Leptin receptor C-terminus |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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瘦素受体抗体(长)Anti-Leptin receptor(long)的相关产品目录:
1mg/1ml 瘦素受体抗体(长) Anti-Leptin receptor(long) obl; CD 295; CD295; CD295 antigen; Db; Fa; HuB219; LEP R; LEPR; LEPROT; Leptin receptor fa的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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