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磷酸化干扰素调节因子3 田源一抗磷酸化抗体
点击次数:189发布时间:2012/8/7 16:06:17
更新日期:2013/6/7 10:38:52
所 在 地:其它
产品型号:Anti-Phospho-IRF3 (Ser396)
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详细内容
磷酸化干扰素调节因子3Anti-Phospho-IRF3 (Ser396)Interferon regulatory factor 3; IRF-3; IRF 3.
360TIYO.COM-上海田源公司
性能参数:
中文名称:磷酸化干扰素调节因子3
英文名称:Anti-Phospho-IRF3 (Ser396)
别名:Interferon regulatory factor 3; IRF-3; IRF 3.
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:This protein is a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.Subcellular Location : Cytoplasm. Nucleus. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.Tissue Specificity : Expressed constitutively in a variety of tissues.Similarity : Belongs to the IRF family. Contains 1 IRF tryptophan pentad repeat DNA-binding domain.Subunit : Homodimer; phosphorylation-induced. Interacts with CREBBP. May interact with MAVS. Interacts with IKBKE and TBK1. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1 (via C-terminus); this interaction leads to the proteasome-dependent degradation of IRF3. Interacts with RBCK1. Interacts with TRIM21. Interacts with HERC5.干扰素调节因子家族是一大类对干扰素起调控作用的转录因子的统称。 一般认为干扰素调节因子(IRF)通过调节干扰素的表达而行使其抗病毒、应激、免疫调节功能。近年来,研究人员发现IRF在细胞凋亡、细胞周期、细胞分化、肿瘤发生中也起着重要的调节作用。磷酸化干扰素调节因子3的质量标准:
■其它名称: | Interferon regulatory factor 3; IRF-3; IRF 3. |
■交叉反应: | hu, rat, mo |
■产品类型: | 一抗磷酸化抗体 |
■应用领域: | /肿瘤/免疫学/信号转导/细胞凋亡/转录调节因子 |
■蛋白分子: | predicted molecular weight: 44-47kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthesised phosphopeptide derived from human IRF3 around the phosphorylation site of Ser396 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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磷酸化干扰素调节因子3Anti-Phospho-IRF3 (Ser396)的相关产品目录:
1mg/1ml 磷酸化干扰素调节因子3 Anti-Phospho-IRF3 (Ser396) Interferon regulatory factor 3; IRF-3; IRF 3.的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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