甲基化CpG结合蛋白抗体Anti-MBD1/PCM1CXXC 3; CXXC3; MBD 1; MBD1; MECP1 COMPLEX; Methyl CpG binding domain protein 1; Methyl CpG
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性能参数：

中文名称：甲基化CpG结合蛋白抗体
英文名称：Anti-MBD1/PCM1
别名：CXXC 3; CXXC3; MBD 1; MBD1; MECP1 COMPLEX; Methyl CpG binding domain protein 1; Methyl CpG
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development ａnd regulates gene expression. The methylation pattern involves the enzymatic processes of methylation ａnd demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain （MBD）. The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 ａnd MBD1 （PCM1） are first found to repress transcription by binding specifically to methylated DNA. MBD2 ａnd MBD4 （also known as MED1） were later found to colocalize with foci of heavily methylated satellite DNA ａnd believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo ａnd in vitro. MBD1, MBD2, MBD3, ａnd MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 ａnd MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract. Subcellular Location : Nucleus speckle. Chromosome.Tissue Specificity : Widely expressed.Similarity : Contains 3 CXXC-type zinc fingers.Contains 1 MBD （methyl-CpG-binding） domain.

甲基化CpG结合蛋白抗体的质量标准：

■其它名称：	CXXC 3; CXXC3; MBD 1; MBD1; MECP1 COMPLEX; Methyl CpG binding domain protein 1; Methyl CpG
■交叉反应：	hu, mo, rat
■产品类型：	一抗
■应用领域:	/细胞生物/免疫学/染色质和核信号/细胞周期蛋白/细胞分化
■蛋白分子：	predicted molecular weight: 60kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human MBD1
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
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甲基化CpG结合蛋白抗体Anti-MBD1/PCM1的相关产品目录：







1mg/1ml 甲基化CpG结合蛋白抗体 Anti-MBD1/PCM1 CXXC 3; CXXC3; MBD 1; MBD1; MECP1 COMPLEX; Methyl CpG binding domain protein 1; Methyl CpG的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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