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髓过氧化物酶抗体 田源一抗
点击次数:164发布时间:2012/8/8 20:30:39
更新日期:2013/6/7 10:37:06
所 在 地:其它
产品型号:Anti-MPO/Myeloperoxidase
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详细内容
髓过氧化物酶抗体Anti-MPO/MyeloperoxidaseMyeloperoxidase; MPO; Contains: 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxi
360TIYO.COM-上海田源公司
性能参数:
中文名称:髓过氧化物酶抗体
英文名称:Anti-MPO/Myeloperoxidase
别名:Myeloperoxidase; MPO; Contains: 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxi
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Myeloperoxidase is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains (MW 59 - 64 kDa) and two unglycosylated beta chains (MW 14 kDa) with total MW 150 kDa and theoretical pI 9.2. Traditionally Myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that Myeloperoxidase participates in the initiation and progression of cardiovascular disease. It possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers.Subcellular Location : Lysosome.Similarity : Belongs to the peroxidase family. XPO subfamily.Subunit : Tetramer of two light chains and two heavy chains.髓过氧化物酶MPO,作为一种白细胞酶,具有介导炎性反应、调节免疫应答等多种功能,并可参与疾病的发生发展过程。同时,髓过氧化物酶基因存在基因多态性,也影响机体对疾病的易感性. 在正常淋巴组织中和各种髓样细胞增生症中,MPO均有较强表达,如:淋巴样细胞、原核细胞、肥大细胞、浆细胞以及各种上皮源性肿瘤和肉瘤等。髓过氧化物酶抗体的质量标准:
■其它名称: | Myeloperoxidase; MPO; Contains: 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxi |
■交叉反应: | hu, mo, rat, cow, hrs, Rb, dog |
■产品类型: | 一抗 |
■应用领域: | /细胞生物/免疫学 |
■蛋白分子: | predicted molecular weight: 77kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human MPO N-terminus |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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髓过氧化物酶抗体Anti-MPO/Myeloperoxidase的相关产品目录:
1mg/1ml 髓过氧化物酶抗体 Anti-MPO/Myeloperoxidase Myeloperoxidase; MPO; Contains: 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxi的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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