磷酸化DNA修复蛋白NBS1抗体Anti-Phospho-p95/NBS1 （Ser343）p95/NBS1（Phospho-Ser343）; Nijmegen breakage syndrome 1; Nijmegen breakage syndrome 1 （nibr
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性能参数：

中文名称：磷酸化DNA修复蛋白NBS1抗体
英文名称：Anti-Phospho-p95/NBS1 （Ser343）
别名：p95/NBS1（Phospho-Ser343）; Nijmegen breakage syndrome 1; Nijmegen breakage syndrome 1 （nibr
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Component of the MRE11/RAD50/NBN （MRN complex） which plays a critical role in the cellular response to DNA damage ａnd the maintenance of chromosome integrity. The complex is involved in double-strand break （DSB） repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control ａnd meiosis. The complex possesses single-strand endonuclease activity ａnd double-strand-specific 3＇-5＇ exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends ａnd hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, ａnd probably DNA-PKcs to the DNA damage sites ａnd activating their functions. It can also recruit MRE11 ａnd RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3＇ overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint ａnd there is some evidence that NBN is involved in G1 ａnd G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, ａnd effector, which enable cells to maintain DNA integrity ａnd genomic stability.NBS1蛋白可与Mre11和Rad50蛋白形成一个Mre11-Rad50-NBS1复合物,在DNA的复制和DNA双链断裂的修复等过程中起重要作用。

磷酸化DNA修复蛋白NBS1抗体的质量标准：

■其它名称：	p95/NBS1（Phospho-Ser343）; Nijmegen breakage syndrome 1; Nijmegen breakage syndrome 1 （nibr
■交叉反应：	hu, mo, rat
■产品类型：	一抗磷酸化抗体
■应用领域:	/肿瘤/细胞生物/免疫学/信号转导/细胞凋亡/转录调节因子
■蛋白分子：	predicted molecular weight: 95kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human p95/NBS1 around the phosphorylation site of Ser343
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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磷酸化DNA修复蛋白NBS1抗体Anti-Phospho-p95/NBS1 （Ser343）的相关产品目录：







1mg/1ml 磷酸化DNA修复蛋白NBS1抗体 Anti-Phospho-p95/NBS1 （Ser343） p95/NBS1（Phospho-Ser343）; Nijmegen breakage syndrome 1; Nijmegen breakage syndrome 1 （nibr的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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