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磷酸化雷帕霉素靶蛋白抗体 田源一抗磷酸化抗体
点击次数:149发布时间:2012/8/8 20:34:47
更新日期:2013/6/7 10:34:07
所 在 地:其它
产品型号:Anti-Phospho-mTOR (Thr2446)
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详细内容
磷酸化雷帕霉素靶蛋白抗体Anti-Phospho-mTOR (Thr2446)Mammalian target of rapamycin; FKBP12 rapamycin associated protein; FK506 binding protein
360TIYO.COM-上海田源公司
性能参数:
中文名称:磷酸化雷帕霉素靶蛋白抗体
英文名称:Anti-Phospho-mTOR (Thr2446)
别名:Mammalian target of rapamycin; FKBP12 rapamycin associated protein; FK506 binding protein
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:mTOR is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 289-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.mTOR蛋白是一种丝氨酸/苏氨酸蛋白激酶(Ser/Thr),是调节细胞生长和增殖的重要信号转导分子,在细胞的生长、分化、增殖、迁移和存活上扮演了重要的角色。由于mTOR信号通路在细胞周期进程中发挥了重要作用,细胞周期进程调节异常与许多疾病尤其是癌症的发生、发展有关,mTOR信号通路的失调可引起多种肿瘤的发生。磷酸化雷帕霉素靶蛋白抗体的质量标准:
■其它名称: | Mammalian target of rapamycin; FKBP12 rapamycin associated protein; FK506 binding protein |
■交叉反应: | hu, mo, rat, cow, Rb, shp, hrs, dog |
■产品类型: | 一抗磷酸化抗体 |
■应用领域: | /肿瘤/免疫学/细胞凋亡/生长因子和激素/转录调节因子 |
■蛋白分子: | predicted molecular weight: 280kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated Synthesised phosphopeptide derived from human mTOR around the phosphorylation site of Thr2446 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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磷酸化雷帕霉素靶蛋白抗体Anti-Phospho-mTOR (Thr2446)的相关产品目录:
1mg/1ml 磷酸化雷帕霉素靶蛋白抗体 Anti-Phospho-mTOR (Thr2446) Mammalian target of rapamycin; FKBP12 rapamycin associated protein; FK506 binding protein 的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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