产品展示
磷酸化双微体2癌基因抗体 田源一抗磷酸化抗体
点击次数:140发布时间:2012/8/8 20:34:51
更新日期:2013/6/7 10:34:07
所 在 地:其它
产品型号:Anti-Phospho-MDM2(Ser185)
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详细内容
磷酸化双微体2癌基因抗体Anti-Phospho-MDM2(Ser185)MDM2(phospho S185); Double minute 2 protein; Hdm 2; HDM2; MDM 2; Mdm2 transformed 3T3 cell
360TIYO.COM-上海田源公司
性能参数:
中文名称:磷酸化双微体2癌基因抗体
英文名称:Anti-Phospho-MDM2(Ser185)
别名:MDM2(phospho S185); Double minute 2 protein; Hdm 2; HDM2; MDM 2; Mdm2 transformed 3T3 cell
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Inhibits TP53/p53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Binds p53, p73, ARF(P14), ribosomal protein L5 and specifically to RNA. Can interact also with retinoblastoma protein(RB), E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with TP53/p53 and WWOX. Interacts with CDKN2AIP, MTBP, TRBG1 and USP7. Isoform Mdm2-F does not interact with TP53/p53. Interacts with PYHIN1. Interacts with, and ubiquitinates HIV-1 Tat. Belongs to the MDM2/MDM4 family.Mdm2基因在肿瘤发生、发展的过程中起着重要作用,Mdm2蛋白过度表达与p53基因突变有重要的关联性。Mdm2基因在肿瘤发生、发展的过程中起着重要作用。磷酸化双微体2癌基因抗体的质量标准:
■其它名称: | MDM2(phospho S185); Double minute 2 protein; Hdm 2; HDM2; MDM 2; Mdm2 transformed 3T3 cell |
■交叉反应: | hu, mo, rat |
■产品类型: | 一抗磷酸化抗体 |
■应用领域: | /肿瘤/免疫学/信号转导/细胞凋亡/转录调节因子/激酶和磷酸酶 |
■蛋白分子: | predicted molecular weight: 55kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated Synthesised phosphopeptide derived from human MDM2 around the phosphorylation site of Ser185 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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磷酸化双微体2癌基因抗体Anti-Phospho-MDM2(Ser185)的相关产品目录:
1mg/1ml 磷酸化双微体2癌基因抗体 Anti-Phospho-MDM2(Ser185) MDM2(phospho S185); Double minute 2 protein; Hdm 2; HDM2; MDM 2; Mdm2 transformed 3T3 cell的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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