细胞核因子p100/p52k基因结合核因子抗体Anti-NFkB p100/p52DNA binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10; Lyt10;
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性能参数：

中文名称：细胞核因子p100/p52k基因结合核因子抗体
英文名称：Anti-NFkB p100/p52
别名：DNA binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10; Lyt10;
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types ａnd is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis ａnd apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL ａnd NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes ａnd the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity ａnd specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification ａnd subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor （I-kappa-B） family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases （IKKs） in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 ａnd the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 ａnd generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 ａnd p100 ａnd preserves their independent function. p52 binds to the kappa-B consensus sequence 5＇-GGRNNYYCC-3＇, located in the enhancer region of genes involved in immune response ａnd acute phase reactions. p52 ａnd p100 are respectively the minor ａnd major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65.

细胞核因子p100/p52k基因结合核因子抗体的质量标准：

■其它名称：	DNA binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10; Lyt10;
■交叉反应：	hu, mo, rat
■产品类型：	一抗
■应用领域:	/肿瘤/染色质和核信号/信号转导/细胞凋亡/转录调节因子
■蛋白分子：	predicted molecular weight: 50/ 100kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human NFkB p100/p52
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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细胞核因子p100/p52k基因结合核因子抗体Anti-NFkB p100/p52的相关产品目录：







1mg/1ml 细胞核因子p100/p52k基因结合核因子抗体 Anti-NFkB p100/p52 DNA binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10; Lyt10; 的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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