磷酸化肿瘤抑制基因P53抗体Anti-phospho-P53（Ser33）p53 （Phospho-Ser33）; Antigen NY-CO-13; Cellular tumor antigen p53; Cys 51 Stop; HGNC11998;
360TIYO.COM-上海田源公司

性能参数：

中文名称：磷酸化肿瘤抑制基因P53抗体
英文名称：Anti-phospho-P53（Ser33）
别名：p53 （Phospho-Ser33）; Antigen NY-CO-13; Cellular tumor antigen p53; Cys 51 Stop; HGNC11998;
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：p53 plays a major role in the cellular response to DNA damage ａnd other genomic aberrations. The activation of p53 can lead to either cell cycle arrest ａnd DNA repair, or apoptosis. p53 is phosphorylated at multiple sites in vivo ａnd by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, ａnd DNAPK at Ser15; the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation ａnd functional activation of p53 in response to DNA damage. Chk2 ａnd Chk1 can phosphorylate p53 at Ser20, enhancing its tetramerization, stability ａnd activity. p53 is phosphorylated at Ser392 in vivo ａnd by CAK in vitro. Phosphorylation of p53 at Ser392 is altered in human tumors ａnd has been reported to influence the growth suppressor function, DNA binding ａnd transcriptional activation of p53. p53 is phosphorylated at Ser6 ａnd Ser9 by ck1d ａnd ck1e both in vitro ａnd in vivo. Phosphorylation of p53 at Ser46 is important in regulating the ability of p53 to induce apoptosis. In vivo phosphorylation of p53 at Ser33 by cdk7/cyclin H ａnd in response to UV irradiation has been observed.

磷酸化肿瘤抑制基因P53抗体的质量标准：

■其它名称：	p53 （Phospho-Ser33）; Antigen NY-CO-13; Cellular tumor antigen p53; Cys 51 Stop; HGNC11998;
■交叉反应：	hu, hrs
■产品类型：	一抗磷酸化抗体
■应用领域:	/肿瘤/免疫学/信号转导/转录调节因子
■蛋白分子：	predicted molecular weight: 43kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human P53 around the phosphorylation site of Ser33
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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由于化学产品的特殊性，恕不接受以下投诉：
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磷酸化肿瘤抑制基因P53抗体Anti-phospho-P53（Ser33）的相关产品目录：







1mg/1ml 磷酸化肿瘤抑制基因P53抗体 Anti-phospho-P53（Ser33） p53 （Phospho-Ser33）; Antigen NY-CO-13; Cellular tumor antigen p53; Cys 51 Stop; HGNC11998;的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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