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跨膜受体蛋白Notch-2抗体 田源一抗
点击次数:130发布时间:2012/8/9 11:53:42
更新日期:2013/6/6 11:43:29
所 在 地:其它
产品型号:Anti-Notch 2
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详细内容
跨膜受体蛋白Notch-2抗体Anti-Notch 2Neurogenic locus notch homolog protein 2; Notch2; hN2; Notch 2 extracellular truncation; N
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性能参数:
中文名称:跨膜受体蛋白Notch-2抗体
英文名称:Anti-Notch 2
别名:Neurogenic locus notch homolog protein 2; Notch2; hN2; Notch 2 extracellular truncation; N
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.Subcellular Location : Cell membrane; Single-pass type I membrane protein. Notch 2 intracellular domain: Nucleus. Tissue Specificity : Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.Similarity : Belongs to the NOTCH family. Contains 6 ANK repeats.Contains 35 EGF-like domains.Contains 3 LNR (Lin/Notch) repeats.Subunit : Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity).Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH2. Interacts with RELA/p65 (By similarity).跨膜受体蛋白Notch-2抗体的质量标准:
■其它名称: | Neurogenic locus notch homolog protein 2; Notch2; hN2; Notch 2 extracellular truncation; N |
■交叉反应: | hu, mo, rat, pig, Rb |
■产品类型: | 一抗 |
■应用领域: | /免疫学/干细胞/细胞膜受体 |
■蛋白分子: | predicted molecular weight: 271kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human Notch2 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//Flow-Cyt=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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跨膜受体蛋白Notch-2抗体Anti-Notch 2的相关产品目录:
1mg/1ml 跨膜受体蛋白Notch-2抗体 Anti-Notch 2 Neurogenic locus notch homolog protein 2; Notch2; hN2; Notch 2 extracellular truncation; N的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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