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磷酸化丝氨酸/苏氨酸激酶p90RSK蛋白抗体 田源一抗磷酸化抗体
点击次数:175发布时间:2012/8/9 11:56:29
更新日期:2013/6/6 11:14:05
所 在 地:其它
产品型号:Anti-Phospho-p90RSK(Ser380)
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详细内容
磷酸化丝氨酸/苏氨酸激酶p90RSK蛋白抗体Anti-Phospho-p90RSK(Ser380)p90 RSK1; p90rsk; p90S6K; pp90RSK1; Ribosomal protein S6 kinase 90kD 1; Ribosomal protein
360TIYO.COM-上海田源公司
性能参数:
中文名称:磷酸化丝氨酸/苏氨酸激酶p90RSK蛋白抗体
英文名称:Anti-Phospho-p90RSK(Ser380)
别名:p90 RSK1; p90rsk; p90S6K; pp90RSK1; Ribosomal protein S6 kinase 90kD 1; Ribosomal protein
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Rsk1 is a member of a family of 90kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB.p90RSK蛋白属于广泛表达的丝氨酸/苏氨酸激酶。RSK家族包括RSK1、RSK2、RSK3和RSK4,它们的典型特征是含有两个不同的功能性激酶结构域和羧基端ERKs(extracellular signal-regulated kinases)结合结构域。RSK激酶结构域内外的几个位点包括Ser380、Thr359、Ser363和Thr573的磷酸化都对RSK的激酶活性激活非常重要。RSK1-3可被MAPKs所磷酸化激活,也可以通过自身磷酸化激活,还可被一些生长因子或神经递质等诱导激活的PI3K信号通路所激活。RSK在被MAPK磷酸化激活时,是由Ras、Raf-1、MAP kinase kinase(MEK)和MAP kinase信号通路所介导。PI3K诱导的RSK1激活是由丝氨酸/苏氨酸激酶mTOR介导的。RSK1在葡萄糖稳态调控和细胞大小的调控中起重要作用。RSK可以磷酸化并调节转录因子c-fos和糖原合成酶激酶3(GSK3,glycogen synthase kinase 3)的活性。有报道RSK1可以和MAPK1、IκBα、TOB和TSC2等相互作用。RSK可以在有丝分裂信号刺激下会转位到细胞核内。磷酸化丝氨酸/苏氨酸激酶p90RSK蛋白抗体的质量标准:
■其它名称: | p90 RSK1; p90rsk; p90S6K; pp90RSK1; Ribosomal protein S6 kinase 90kD 1; Ribosomal protein |
■交叉反应: | hu, mo, rat, Rb, pig, hrs, cow, dog |
■产品类型: | 一抗磷酸化抗体 |
■应用领域: | /肿瘤/免疫学/信号转导/细胞凋亡/转录调节因子/激酶和磷酸酶 |
■蛋白分子: | predicted molecular weight: 90kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated Synthesised phosphopeptide derived from human p90RSK around the phosphorylation site of Ser380 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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磷酸化丝氨酸/苏氨酸激酶p90RSK蛋白抗体Anti-Phospho-p90RSK(Ser380)的相关产品目录:
1mg/1ml 磷酸化丝氨酸/苏氨酸激酶p90RSK蛋白抗体 Anti-Phospho-p90RSK(Ser380) p90 RSK1; p90rsk; p90S6K; pp90RSK1; Ribosomal protein S6 kinase 90kD 1; Ribosomal protein 的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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上海田源专业销售磷酸化丝氨酸/苏氨酸激酶p90RSK蛋白抗体 Anti-Phospho-p90RSK(Ser380),了解更多请点击查询!