产品展示
肿瘤抑制基因P53蛋白抗体(野生型P53) 田源一抗
点击次数:163发布时间:2012/8/9 11:56:39
更新日期:2013/6/6 11:14:05
所 在 地:其它
产品型号:Anti-P53 protein(wt-p53)
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详细内容
肿瘤抑制基因P53蛋白抗体(野生型P53)Anti-P53 protein(wt-p53)Widespread p53; Wtp53; Antigen NY-CO-13; Cellular tumor antigen p53; Cys 51 Stop; HGNC1199
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性能参数:
中文名称:肿瘤抑制基因P53蛋白抗体(野生型P53)
英文名称:Anti-P53 protein(wt-p53)
别名:Widespread p53; Wtp53; Antigen NY-CO-13; Cellular tumor antigen p53; Cys 51 Stop; HGNC1199
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:The widely studied P53 tumor suppressor gene has been found to contain mutations in over 50% of human cancers. The level of P53 protein is low in normal cells, but is increased in response to DNA damage or various other cellular distress signals. Overexpression of the P53 transcription factor can induce ether cell cycle arrest or apoptosis through transcriptional regulation of several genes including the cell cycle ingibitor P21, DNA repair gene GADD45, and the apoptotic inducer Bax. P53 has also been shown to induce apoptosis by meas of s direct signaling pathway. P53 directly binds to and acts on several cellular protein involved in various pathway, including c-Abl, basal transcription factor TFIIH and WT1. P53 can be functionally inactivated by mutation, binding to DNA tumor virus encoded proteins, such as SV40 large T antigen, Adenovirus E1B and papilloma virus E6 proteins or as a consequence of its interaction with the oncogene-encoded protein MDM2.wtp53广泛的研究发现P53肿瘤抑制基因对50%以上的人类癌症具有抑制突变的功能。P53蛋白水平在正常细胞中表达低,在DNA突变时或各种各样细胞遇难信号时反应增加。该基因突变或缺失是导致许多肿瘤发生的原因。 野生型P53(wt-p53)可诱导细胞凋亡,并通过细胞凋亡抑制肿瘤生长,而P53的突变或缺失则可抑制野生型P53的功能,使得缺陷细胞得以存活下来,从而导致肿瘤发生。P53同时也是细胞凋亡的调控因子。此抗体可用于P53肿瘤抑制基因功能的研究。肿瘤抑制基因P53蛋白抗体(野生型P53)的质量标准:
■其它名称: | Widespread p53; Wtp53; Antigen NY-CO-13; Cellular tumor antigen p53; Cys 51 Stop; HGNC1199 |
■交叉反应: | hu, mo, rat, cow, Rb, pig, shp, hrs |
■产品类型: | 一抗 |
■应用领域: | /肿瘤/细胞生物/染色质和核信号/细胞凋亡/细胞周期蛋白 |
■蛋白分子: | predicted molecular weight: 53kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human P53 C-terminus |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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肿瘤抑制基因P53蛋白抗体(野生型P53)Anti-P53 protein(wt-p53)的相关产品目录:
1mg/1ml 肿瘤抑制基因P53蛋白抗体(野生型P53) Anti-P53 protein(wt-p53) Widespread p53; Wtp53; Antigen NY-CO-13; Cellular tumor antigen p53; Cys 51 Stop; HGNC1199的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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