突变型P53抗体Anti-Mtp53（N235K N239Y）Mutant type p53（N235K N239Y）; Chain A, Human P53 Core Domain Mutant N239y; Human P53 Core
360TIYO.COM-上海田源公司

性能参数：

中文名称：突变型P53抗体
英文名称：Anti-Mtp53（N235K N239Y）
别名：Mutant type p53（N235K N239Y）; Chain A, Human P53 Core Domain Mutant N239y; Human P53 Core
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－

产品详细描述

产品介绍：The widely studied P53 tumor suppressor gene has been found to contain mutations in over 50% of human cancers. The level of P53 protein is low in normal cells, but is increased in response to DNA damage or various other cellular distress signals. Overexpression of the P53 transcription factor can induce ether cell cycle arrest or apoptosis through transcriptional regulation of several genes including the cell cycle ingibitor P21, DNA repair gene GADD45, ａnd the apoptotic inducer Bax. P53 has also been shown to induce apoptosis by meas of s direct signaling pathway. P53 directly binds to ａnd acts on several cellular protein involved in various pathway, including c-Abl, basal transcription factor TFIIH ａnd WT1. P53 can be functionally inactivated by mutation, binding to DNA tumor virus encoded proteins, such as SV40 large T antigen, Adenovirus E1B ａnd papilloma virus E6 proteins or as a consequence of its interaction with the oncogene-encoded protein MDM2. This antibody is recognize the Human P53 Core Domain Mutant N235KN239Y.p53蛋白是一个细胞周期相关蛋白,分为野生型（Wtp53, Widespread p53）及突变型（Mtp53, mutant type p53）两种。 虽然Mtp53蛋白已经丧失抑制细胞增殖的能力,但可能参与调节某些与细胞分化和增殖有关的基因表达。

突变型P53抗体的质量标准：

■其它名称：	Mutant type p53（N235K N239Y）; Chain A, Human P53 Core Domain Mutant N239y; Human P53 Core
■交叉反应：	hu
■产品类型：	一抗
■应用领域:
■蛋白分子：	predicted molecular weight: 21kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human Mtp53 arund the N235K N239Y
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－

质量投诉流程
1、向我们的客户服务部反应投诉原因及订单信息。
2、向我们发送投诉相关的证明材料。
3、田源时间进行质量投诉调查及处理调查结果。
4、田源将联系客户并提供质量投诉处理结果。

友情提醒：
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
1、超过质量投诉期的进口产品投诉
2、非质量报告提及的指标投诉

突变型P53抗体Anti-Mtp53（N235K N239Y）的相关产品目录：







1mg/1ml 突变型P53抗体 Anti-Mtp53（N235K N239Y） Mutant type p53（N235K N239Y）; Chain A, Human P53 Core Domain Mutant N239y; Human P53 Core 的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

查询其它抗体目录请点击本公司化工仪器网链接：http://www.chem17.com/st233816/erlist_675408.html

上海田源专业销售突变型P53抗体 Anti-Mtp53（N235K N239Y），了解更多请点击查询！