核仁磷酸蛋白抗体Anti-NPM/TRK fused gene/NucleophosminNMP1; NO38; NPM 1; NPM; NPM1; Nucleolar Phosphoprotein B23; Nucleolar protein NO38; Nucleo
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性能参数：

中文名称：核仁磷酸蛋白抗体
英文名称：Anti-NPM/TRK fused gene/Nucleophosmin
别名：NMP1; NO38; NPM 1; NPM; NPM1; Nucleolar Phosphoprotein B23; Nucleolar protein NO38; Nucleo
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Nucleophosmin （NPM） also called B23, nutramin ａnd NO38 is a ubiquitously expressed phosphoprotein involved in ribosome assembly/transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, ａnd regulation of p53. It is involved in the acute response of mammalian cells to environmental stress, such as UV rays. NPM continuously shuttles between the nucleus ａnd cytoplasm. It has been shown to bind nucleic acid, prevent protein aggregation via its chaperone activities, protect enzymes during thermal denaturation, ａnd facilitate renaturation of chemically denatured proteins. In its cellular structure role, there is evidence suggesting NPM is associated with the centrosome. It is the substrate of CDK2/cyclin E during duplication of centrosomes （cellular division）.Because of NPM gene interaction with several tumor-associated chromosome translocations, NPM is thought to be a portion of several fusion proteins: NPM-ALK, NPM-RAR, ａnd NPM-MLF1. While it is not thought to be part of the transforming potential of these fusion proteins, it is believed to act as the interface for oligomerization ａnd oncogenic conversion of these tumor promoting fusion proteins.Subcellular Location : Nucleus, nucleolus. Nucleus, nucleoplasm.Similarity : Belongs to the nucleoplasmin family.核仁磷酸蛋白（nucleophosmin）是雌激素调控的一种核仁蛋白， Nucleophosmin（又称为NPM、B23、Numatrin、NO38）位于核仁的颗粒区,与其他一些核蛋白如C23、P120等可相互作用。NPM是一种主要位于核的核与胞浆穿梭蛋白，能调节ARF-p53肿瘤抑制通路。NPM是一种主要的核仁蛋白，在肿瘤或增殖细胞中的表达量比正常静止细胞中多20多倍。研究资料表明，转录因子YY1在NPM基因的表达中可能发挥作用。 NPM可以在细胞核与细胞浆之间穿梭,其定位受细胞周期及一些细胞毒药物的影响。NPM基因在多种人类肿瘤中过表达,因此被公认为肿瘤标志物和癌基因.后来研究发现NPM也具有抑制肿瘤的功能,它的缺失、突变甚至重排与多种肿瘤的发生密切相关.

核仁磷酸蛋白抗体的质量标准：

■其它名称：	NMP1; NO38; NPM 1; NPM; NPM1; Nucleolar Phosphoprotein B23; Nucleolar protein NO38; Nucleo
■交叉反应：	hu, mo, rat, cow, hrs, pig, dog, Rb
■产品类型：	一抗
■应用领域:	/肿瘤/细胞生物/免疫学/信号转导/细胞凋亡/细胞周期蛋白/转录调节因子
■蛋白分子：	predicted molecular weight: 32kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human NPM
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//IHC-P=1:100-500//IHC-F=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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质量投诉流程
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部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
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核仁磷酸蛋白抗体Anti-NPM/TRK fused gene/Nucleophosmin的相关产品目录：







1mg/1ml 核仁磷酸蛋白抗体 Anti-NPM/TRK fused gene/Nucleophosmin NMP1; NO38; NPM 1; NPM; NPM1; Nucleolar Phosphoprotein B23; Nucleolar protein NO38; Nucleo的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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