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跨膜受体蛋白Notch-1抗体 田源一抗
点击次数:229发布时间:2012/8/9 11:59:07
更新日期:2013/6/6 11:13:04
所 在 地:其它
产品型号:Anti-Notch1/MOTC
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详细内容
跨膜受体蛋白Notch-1抗体Anti-Notch1/MOTChN1;Lin-12;LIN12;MIS6;Motch A;mT14;Neurogenic locus notch homolog protein 1;
360TIYO.COM-上海田源公司
性能参数:
中文名称:跨膜受体蛋白Notch-1抗体
英文名称:Anti-Notch1/MOTC
别名:hN1;Lin-12;LIN12;MIS6;Motch A;mT14;Neurogenic locus notch homolog protein 1;
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Notch is a family of single-pass transmembrane receptor proteins that are synthesized in the endoplasmic reticulum as an inactive form and are proteolytically cleaved on an extracellular site by a furin-like convertase (S1 cleavage) in the trans-golgi network after the recognition of the RQRR sequence before it reaches the plasma membrane as heterodimers to yield an active, ligand-accessible form. The Notch family is comprised of 4 members (1-4) whose ligands include the Delta and Jagged family of ligands. These ligands cause proteolysis of Notch to liberate the intracellular domain. Cleavage results in a C-terminal fragment N(TN) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase between gly1743 and val1744 (S3 cleavage) to release the intracellular domain (NICD) from the membrane. That domain translocates to the nucleus and initiates transcription events by binding the DNA binding protein CSL. The notch family members are involved cell differentiation and development.Subcellular Location : Cell membrane and Nucleus. Following proteolytical processing NICD is translocated to the nucleus.Notch 1蛋白是一个进化上保守的跨膜受体家族,广泛分布和表达在多个物种之中。研究发现Notchl作为一条信号转导途径,不仅对正常组织、细胞的分化、发育起重要作用,而且和一些肿瘤的发生和生长相关,有学者发现Notchl在许多实体瘤中异常表达,如:如宫颈癌、子宫内膜癌、肾癌、肺癌、乳腺癌、神经母细胞瘤等。因此Notchl作为一种预防和治疗肿瘤的新途径越来越受到人们的重视。跨膜受体蛋白Notch-1抗体的质量标准:
■其它名称: | hN1;Lin-12;LIN12;MIS6;Motch A;mT14;Neurogenic locus notch homolog protein 1; |
■交叉反应: | hu, mo, rat |
■产品类型: | 一抗 |
■应用领域: | /神经生物学 |
■蛋白分子: | predicted molecular weight: 270kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human Notch1 C-terminus |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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跨膜受体蛋白Notch-1抗体Anti-Notch1/MOTC的相关产品目录:
1mg/1ml 跨膜受体蛋白Notch-1抗体 Anti-Notch1/MOTC hN1;Lin-12;LIN12;MIS6;Motch A;mT14;Neurogenic locus notch homolog protein 1;的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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