α型-过氧化酶活化增生受体抗体Anti-PPAR alphahPPAR; MGC2237; MGC2452; NR1C1; Nuclear receptor subfamily 1 group C member 1; Peroxisome
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性能参数：

中文名称：α型-过氧化酶活化增生受体抗体
英文名称：Anti-PPAR alpha
别名：hPPAR; MGC2237; MGC2452; NR1C1; Nuclear receptor subfamily 1 group C member 1; Peroxisome
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Peroxisome proliferators are nongenotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed Peroxisome Proliferator Activated Receptors （PPARs）. Nuclear hormone receptors are ligand dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPARs are activated by peroxisome proliferators such as clofibric acid, nafenopin, ａnd WY-14,643, as well as by some fatty acids. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase ａnd cytochrome P450 A6 （CYP450 A6） through interaction with specific response elements. PPAR alpha is activated by free fatty acids including linoleic, arachidonic, ａnd oleic acids. Induction of peroxisomes by this mechanism leads to a reduction in blood triglyceride levels. PPAR alpha is expressed mainly in skeletal muscle, heart, liver, ａnd kidney ａnd is thought to regulate many genes involved in the beta-oxidation of fatty acids. Activation of rat liver PPAR alpha has been shown to suppress hepatocyte apoptosis. PPAR alpha, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor （RXR） alpha to form a transcriptionally competent complex.Subcellular Location : Nucleus.Tissue Specificity : Skeletal muscle, liver, heart ａnd kidney.Similarity : Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain.Subunit : Heterodimer; with RXRA. This heterodimerization is required for DNA binding ａnd transactivation activity. Interacts with AKAP13, LPIN1 ａnd PRDM16. Also interacts with PPARBP coactivator in vitro. Interacts with CITED2; the interaction stimulates its transcriptional activity （By similarity）. Interacts with NCOA3 ａnd NCOA6 coactivators. Interacts with ASXL1 AND ASXL2.

α型-过氧化酶活化增生受体抗体的质量标准：

■其它名称：	hPPAR; MGC2237; MGC2452; NR1C1; Nuclear receptor subfamily 1 group C member 1; Peroxisome
■交叉反应：	hu, mo, rat, Rb, chk, cow, hrs, pig
■产品类型：	一抗
■应用领域:	/肿瘤/免疫学/信号转导/转录调节因子/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 51kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human PPAR alpha
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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α型-过氧化酶活化增生受体抗体Anti-PPAR alpha的相关产品目录：







1mg/1ml α型-过氧化酶活化增生受体抗体 Anti-PPAR alpha hPPAR; MGC2237; MGC2452; NR1C1; Nuclear receptor subfamily 1 group C member 1; Peroxisome 的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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