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磷酸化前病毒整合位点蛋白1抗体 田源一抗磷酸化抗体
点击次数:137发布时间:2012/8/10 11:10:59
更新日期:2013/6/6 11:08:01
所 在 地:其它
产品型号:Anti-Phospho-PIM1(Tyr218)
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详细内容
磷酸化前病毒整合位点蛋白1抗体Anti-Phospho-PIM1(Tyr218)Oncogene PIM 1; Oncogene PIM1; PIM 1; Pim 1 kinase; Pim 1 oncogene; PIM; Pim2; PIM3; Proto
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性能参数:
中文名称:磷酸化前病毒整合位点蛋白1抗体
英文名称:Anti-Phospho-PIM1(Tyr218)
别名:Oncogene PIM 1; Oncogene PIM1; PIM 1; Pim 1 kinase; Pim 1 oncogene; PIM; Pim2; PIM3; Proto
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:PIM1 is a member of the serine/threonine kinase PIM oncogene family. PIM1 has been implicated in lymphomagenesis, cell proliferation, apoptosis, differentiation and tumourigenesis. The PIM1 protein kinase is upregulated in prostate cancer.Subcellular Location : Isoform 2: Cytoplasm. Nucleus. Isoform 1: Cell membrane.Tissue Specificity : Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.Similarity : Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.Contains 1 protein kinase domain.Subunit : Isoform 2 is isolated as a monomer whereas isoform 1 complexes with other proteins. Binds to RP9. Isoform 1, but not isoform 2, binds BMX. Isoform 2 interacts with CDKN1B and FOXO3. Interacts with BAD. Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM1, ubiquitination and proteasomal degradation. Interacts with HSP90, this interaction stabilizes PIM1 protein levels. Interacts (ubiquitinated form) with HSP70 and promotes its proteosomal degradation. Interacts with CDKN1A. Interacts with CDC25C. Interacts (via N-terminal 96 residues) with CDC25A. Interacts with MAP3K5. Interacts with MYC.PIM1蛋白是丝氨酸/苏氨酸蛋白激酶2家族成员,他参与细胞信号转导、细胞凋亡、转录调节,在很多肿瘤中表达,尤其是前列腺癌,表达水平较高。磷酸化前病毒整合位点蛋白1抗体的质量标准:
■其它名称: | Oncogene PIM 1; Oncogene PIM1; PIM 1; Pim 1 kinase; Pim 1 oncogene; PIM; Pim2; PIM3; Proto |
■交叉反应: | hu, mo, rat, pig, Rb, dog, cow, shp |
■产品类型: | 一抗磷酸化抗体 |
■应用领域: | /肿瘤/免疫学/信号转导/细胞凋亡/转录调节因子/激酶和磷酸酶 |
■蛋白分子: | predicted molecular weight: 45kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated Synthesised phosphopeptide derived from human PIM1 around the phosphorylation site of Tyr218 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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磷酸化前病毒整合位点蛋白1抗体Anti-Phospho-PIM1(Tyr218)的相关产品目录:
1mg/1ml 磷酸化前病毒整合位点蛋白1抗体 Anti-Phospho-PIM1(Tyr218) Oncogene PIM 1; Oncogene PIM1; PIM 1; Pim 1 kinase; Pim 1 oncogene; PIM; Pim2; PIM3; Proto的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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