磷酸二酯酶4A抗体Anti-PDE4AcAMP specific 3 5 cyclic phosphodiesterase 4A; cAMP specific phosphodiesterase; DPDE
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性能参数：

中文名称：磷酸二酯酶4A抗体
英文名称：Anti-PDE4A
别名：cAMP specific 3 5 cyclic phosphodiesterase 4A; cAMP specific phosphodiesterase; DPDE
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Enzymes of the cAMP-dependent phosphodiesterase type 4 （PDE4） family are important in hydrolyzing cAMP produced by G-protein coupled receptor （GPCR） stimulated adenylyl cyclases. In brain, more than 90% of cAMP formed by the stimulation of GPCRs is hydrolyzed by PDE4 enzymes. PDE4 enzymes are also important molecular targets for a variety of therapeutic agents like antidepressants, anti-asthmatics, ａnd anti-inflammatory drugs. PDE4 family comprises 4 genes （PDE4A, B, C ａnd D）; each exhibiting multiple isozymes due to alternate splicing that leads to a larger number of distinct PDE4 variants. Members of the PDE4 family are regulated/activated by phosphorylation/dephosphorylation by cAMP-dependent protein kinase A ａnd phosphatases. Protein-protein interactions ａnd cellular trafficking of PDE4A enzymes play an important role in cAMP compartmentalization ａnd cAMP-dependent signaling. In brain members of the PDE4A, B ａnd D family are associated with GPCRs （adrenergic ａnd dopaminergic） signaling. There are 5 isoforms.

磷酸二酯酶4A抗体的质量标准：

■其它名称：	cAMP specific 3 5 cyclic phosphodiesterase 4A; cAMP specific phosphodiesterase; DPDE
■交叉反应：	hu, mo, rat
■产品类型：	一抗
■应用领域:	/免疫学/神经生物学/信号转导/转录调节因子/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 66kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human PDE4A
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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磷酸二酯酶4A抗体Anti-PDE4A的相关产品目录：







1mg/1ml 磷酸二酯酶4A抗体 Anti-PDE4A cAMP specific 3 5 cyclic phosphodiesterase 4A; cAMP specific phosphodiesterase; DPDE的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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