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p21激活激酶4抗体 田源一抗
点击次数:117发布时间:2012/8/10 11:12:35
更新日期:2013/6/6 11:07:48
所 在 地:其它
产品型号:Anti-PAK4
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详细内容
p21激活激酶4抗体Anti-PAK4p21 activated kinase 4; p21(CDKN1A) activated kinase 4; PAK 4; Protein kinase related to S
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性能参数:
中文名称:p21激活激酶4抗体
英文名称:Anti-PAK4
别名:p21 activated kinase 4; p21(CDKN1A) activated kinase 4; PAK 4; Protein kinase related to S
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:p21-activated kinases (PAKs) belong to the family of serine/threonine kinases involved in the control of various cellular processes, including the cell cycle, dynamics of the cytoskeleton, apoptosis, oncogenic transformation, and transcription. All PAK family members are characterized by the presence of p21-binding domain. p21-activated kinases are regulated by the small GTP-binding proteins Rac and Cdc42, and lipids, which stimulate autophosphorylation and phosphorylation of exogenous substrates. Serine (Ser-474) is the likely autophosphorylation site in the kinase domain of PAK4 in vivo. Phosphospecific antibodies directed against serine 474 detect activated PAK4 on the Golgi membrane when PAK4 is co-expressed with activated Cdc42. Current data strongly implicates PAK-4 in oncogenesis. PAK4 is frequently overexpressed in human tumor cell lines of various tissue origins.丝氨酸/苏氨酸蛋白激酶4 (PAK4)是新发现的一类蛋白因子,在细胞信号转导过程中起很重要的作用,Pak4常在人体的多种组织器官的肿瘤细胞中呈现过表达,他的丝氨酸位点很可能是Pak4酶活性区域中的自身磷酸化位点,丝氨酸到谷氨酸位点的突变体促使其获得了酶活性。在肿瘤遗传学、细胞癌变、细胞凋亡等一些重要的细胞生物学研究中,具有重要的意义。p21激活激酶4抗体的质量标准:
■其它名称: | p21 activated kinase 4; p21(CDKN1A) activated kinase 4; PAK 4; Protein kinase related to S |
■交叉反应: | hu, mo, rat, cow, Rb, dog, chk |
■产品类型: | 一抗 |
■应用领域: | /肿瘤/信号转导/细胞凋亡/转录调节因子/激酶和磷酸酶 |
■蛋白分子: | predicted molecular weight: 64kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human PAK4 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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p21激活激酶4抗体Anti-PAK4的相关产品目录:
1mg/1ml p21激活激酶4抗体 Anti-PAK4 p21 activated kinase 4; p21(CDKN1A) activated kinase 4; PAK 4; Protein kinase related to S的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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