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肽基脯氨酞顺反异构酶Pinl抗体 田源一抗
点击次数:107发布时间:2012/8/10 11:16:00
更新日期:2013/6/6 11:07:18
所 在 地:其它
产品型号:Anti-Pin1
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详细内容
肽基脯氨酞顺反异构酶Pinl抗体Anti-Pin1DOD; NIMA interacting 1; Peptidyl prolyl cis trans isomerase NIMA interacting 1; Peptidyl
360TIYO.COM-上海田源公司
性能参数:
中文名称:肽基脯氨酞顺反异构酶Pinl抗体
英文名称:Anti-Pin1
别名:DOD; NIMA interacting 1; Peptidyl prolyl cis trans isomerase NIMA interacting 1; Peptidyl
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.肽基脯氨酞顺反异构酶Pinl,是调节细胞有丝分裂相关蛋白酶,对细胞周期运行起着非常重要的调控作用。近年来研究表明,肽基脯氨酞顺反异构酶Pinl在多种肿瘤中过表达,是多个致癌信号通路的关键效应分子,可加强和催化多种致癌信号,使其无限放大,*终引起细胞转化和增殖失控。因次,肽基脯氨酞顺反异构酶Pinl越来越引起人们关注,被称为肿瘤发生发展的催化分子。近来该蛋白用于老年痴呆研究的也日渐增多。肽基脯氨酞顺反异构酶Pinl抗体的质量标准:
■其它名称: | DOD; NIMA interacting 1; Peptidyl prolyl cis trans isomerase NIMA interacting 1; Peptidyl |
■交叉反应: | hu, rat, mo |
■产品类型: | 一抗 |
■应用领域: | /肿瘤/免疫学/神经生物学/信号转导/细胞凋亡/转录调节因子/激酶和磷酸酶 |
■蛋白分子: | predicted molecular weight: 18kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human Pin1 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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肽基脯氨酞顺反异构酶Pinl抗体Anti-Pin1的相关产品目录:
1mg/1ml 肽基脯氨酞顺反异构酶Pinl抗体 Anti-Pin1 DOD; NIMA interacting 1; Peptidyl prolyl cis trans isomerase NIMA interacting 1; Peptidyl 的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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