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蛋白质磷酸酶-2A抗体 田源一抗
点击次数:175发布时间:2012/8/10 11:16:09
更新日期:2013/6/6 11:07:18
所 在 地:其它
产品型号:Anti-PP2A alpha/beta
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详细内容
蛋白质磷酸酶-2A抗体Anti-PP2A alpha/betaPPP2CA; PP2A alpha;PP-2A; PP2A-Cα/β; PP2A C; PP2Ac; PP2CA; PPP2CA; Protein phosphatase 2,
360TIYO.COM-上海田源公司
性能参数:
中文名称:蛋白质磷酸酶-2A抗体
英文名称:Anti-PP2A alpha/beta
别名:PPP2CA; PP2A alpha;PP-2A; PP2A-Cα/β; PP2A C; PP2Ac; PP2CA; PPP2CA; Protein phosphatase 2,
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Kinases and Phosphatases Serine/threonine protein phosphatase 2A , catalytic subunit, alpha isoform(APP-2A-alpha) (also designated Replication protein C, RP-C) can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. PP2A consists of a common heterodimeric core enzyme, composed of a 34 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. It belongs to the PPP phosphatase family. PP-1 subfamily.This antibody is crosed with PP-2A subunit A,B,C. 激酶和磷酸酶(Kinases and Phosphatases) PP-2A (protein phosphatase 2A catalytic subunit;PP2A alpha;)参与酵母细胞及两栖类卵母细胞有丝分裂的蛋白丝/苏氨酸磷酸酶。此酶的表达与细胞周期调节有关。此抗体与PP-2A subunit A,B,C 均有交叉反应。蛋白质磷酸酶-2A抗体的质量标准:
■其它名称: | PPP2CA; PP2A alpha;PP-2A; PP2A-Cα/β; PP2A C; PP2Ac; PP2CA; PPP2CA; Protein phosphatase 2, |
■交叉反应: | hu, mo, rat, cow, pig, dog, chk, Rb |
■产品类型: | 一抗 |
■应用领域: | /细胞生物/信号转导/细胞周期蛋白/激酶和磷酸酶 |
■蛋白分子: | predicted molecular weight: 34kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human PP-2A C-terminus |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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蛋白质磷酸酶-2A抗体Anti-PP2A alpha/beta的相关产品目录:
1mg/1ml 蛋白质磷酸酶-2A抗体 Anti-PP2A alpha/beta PPP2CA; PP2A alpha;PP-2A; PP2A-Cα/β; PP2A C; PP2Ac; PP2CA; PPP2CA; Protein phosphatase 2, 的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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