节律抑制蛋白PER1抗体Anti-PER1 proteinPER-1; Circadian clock protein PERIOD 1; Circadian clock protein PERIOD1; Circadian pac
360TIYO.COM-上海田源公司

性能参数：

中文名称：节律抑制蛋白PER1抗体
英文名称：Anti-PER1 protein
别名：PER-1; Circadian clock protein PERIOD 1; Circadian clock protein PERIOD1; Circadian pac
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：In mammals, several genes that encode members of the basic helix-loop helix （bHLH） PAS （PER-ARNT-SIM） transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer （CACGTG） found upstream of target genes. CLOCK-ARNT 3 heterodimers bind to E box regulatory elements ａnd stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila PER. PER, in concert with the product of the mammalian timeless gene （TIM）, negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL 1 transactivation complex.Subcellular Location : Nucleus （By similarity）. Cytoplasm （By similarity）. Note=Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER1 nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2 （By similarity）.Tissue Specificity : Widely expressed. Found in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, kidney, spleen, thymus, prostate, testis, ovary ａnd small intestine. Highest level in skeletal muscle. Low level in kidney.Subunit : Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, ａnd the PER proteins. Interacts directly with TIMELESS, PER2, PER3 and, through a C-terminal domain, with CRY1 ａnd CRY2. Interaction with CSNK1D or CSNK1E promotes nuclear location of PER proteins. Interacts with GPRASP1 （By similarity）. Binding to CSNK1G2 triggers proteasomal degradation.Per1蛋白的作用是机体生理节奏调节的核心基因，也是影响肿瘤发生发展的重要蛋白。调节机体生理节奏、调控细胞周期和促进DNA损伤修复等作用。Per1广泛参与了细胞的周期调控、DNA损伤修复、细胞凋亡和肿瘤细胞增殖等过程

节律抑制蛋白PER1抗体的质量标准：

■其它名称：	PER-1; Circadian clock protein PERIOD 1; Circadian clock protein PERIOD1; Circadian pac
■交叉反应：	hu, mo, rat, dog, hrs, cow, pig, Rb
■产品类型：	一抗
■应用领域:	/肿瘤/细胞生物/免疫学/染色质和核信号/神经生物学
■蛋白分子：	predicted molecular weight: 142kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human PER1 protein
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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质量投诉流程
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部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
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节律抑制蛋白PER1抗体Anti-PER1 protein的相关产品目录：







1mg/1ml 节律抑制蛋白PER1抗体 Anti-PER1 protein PER-1; Circadian clock protein PERIOD 1; Circadian clock protein PERIOD1; Circadian pac的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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