脯氨酸羟化酶2抗体Anti-PHD2SM 20; Zinc finger MYND domain containing protein 6; C1ORF12; Chromosome 1 Open Reading Fr
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性能参数：

中文名称：脯氨酸羟化酶2抗体
英文名称：Anti-PHD2
别名：SM 20; Zinc finger MYND domain containing protein 6; C1ORF12; Chromosome 1 Open Reading Fr
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：PHD2 protein catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor （HIF） alpha proteins. In the presence of oxygen, PHD2 converts specific prolyl residues in HIF alpha to hydroxyproline, leading to HIF alpha proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF levels are stable. This results in increased angiogenesis as HIF1 alpha regulates the expression of many angiogenesis-related genes. Subcellular Location : Cytoplasm. Nucleus.Tissue Specificity : According to PubMed:11056053, widely expressed with highest levels in skeletal muscle ａnd heart, moderate levels in pancreas, brain （dopaminergic neurons of adult ａnd fetal substantia nigra） ａnd kidney, ａnd lower levels in lung ａnd liver. According to PubMed:12351678 widely expressed with highest levels in brain, kidney ａnd adrenal gland. Expressed in cardiac myocytes, aortic endothelial cells ａnd coronary artery smooth muscle. According to PubMed:12788921; expressed in adult ａnd fetal heart, brain, liver, lung, skeletal muscle ａnd kidney. Also expressed in placenta. Highest levels in adult heart, brain, lung ａnd liver ａnd fetal brain, heart spleen ａnd skeletal muscle.Similarity : Contains 1 Fe2OG dioxygenase domain.Contains 1 MYND-type zinc finger.

脯氨酸羟化酶2抗体的质量标准：

■其它名称：	SM 20; Zinc finger MYND domain containing protein 6; C1ORF12; Chromosome 1 Open Reading Fr
■交叉反应：	hu, mo, Rb, cow, pig
■产品类型：	一抗
■应用领域:	/细胞生物/免疫学/神经生物学/细胞凋亡/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 47kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human PHD2
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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由于化学产品的特殊性，恕不接受以下投诉：
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脯氨酸羟化酶2抗体Anti-PHD2的相关产品目录：







1mg/1ml 脯氨酸羟化酶2抗体 Anti-PHD2 SM 20; Zinc finger MYND domain containing protein 6; C1ORF12; Chromosome 1 Open Reading Fr的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

查询其它抗体目录请点击本公司化工仪器网链接：http://www.chem17.com/st233816/erlist_675408.html

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