蛋白激酶AKT底物1抗体Anti-PRAS40/AKT1 substrate 1AKT1 substrate 1 （proline rich）; AKT1 substrate 1; AKT1-S1; AKT1S-1; AKT1S1; Lobe; PRAS 40
360TIYO.COM-上海田源公司

性能参数：

中文名称：蛋白激酶AKT底物1抗体
英文名称：Anti-PRAS40/AKT1 substrate 1
别名：AKT1 substrate 1 （proline rich）; AKT1 substrate 1; AKT1-S1; AKT1S-1; AKT1S1; Lobe; PRAS 40
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Proline Rich Akt Substrate （PRAS40） is a 40 kDa substrate of Akt. Akt ａnd PRAS40 can be found in the phosphoinositide 3 kinase （PI3K） pathway, which plays a role in glucose uptake, cell growth, ａnd apoptosis inhibition. PRAS40 is a 14-3-3 binding protein that reacts with insulin, but whose precise function is not yet known. It may bind SH3 ａnd WW domain containing proteins resulting in a change of function. Activated Akt phosphorylates PRAS40 on threonine 246. Mutation of PRAS40 threonine 246 has been shown to be apoptotic.Subcellular Location : Cytoplasm, cytosol.Tissue Specificity : Widely expressed with highest levels of expression in liver ａnd heart. Expressed at higher levels in cancer cell lines （e.g. A-549 ａnd HeLa） than in normal cell lines （e.g. HEK293）.Subunit : Part of the mammalian target of rapamycin complex 1 （mTORC1） which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 ａnd DEPTOR. mTORC1 binds to ａnd is inhibited by FKBP12-rapamycin. Interacts directly with RPTOR. The phosphorylated form interacts with 14-3-3 proteins.

蛋白激酶AKT底物1抗体的质量标准：

■其它名称：	AKT1 substrate 1 （proline rich）; AKT1 substrate 1; AKT1-S1; AKT1S-1; AKT1S1; Lobe; PRAS 40
■交叉反应：	hu, mo, rat, hrs, cow, dog, pig
■产品类型：	一抗
■应用领域:	/肿瘤/免疫学/细胞凋亡/转录调节因子/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 28kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human PRAS40
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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质量投诉流程
1、向我们的客户服务部反应投诉原因及订单信息。
2、向我们发送投诉相关的证明材料。
3、田源时间进行质量投诉调查及处理调查结果。
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友情提醒：
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
1、超过质量投诉期的进口产品投诉
2、非质量报告提及的指标投诉

蛋白激酶AKT底物1抗体Anti-PRAS40/AKT1 substrate 1的相关产品目录：







1mg/1ml 蛋白激酶AKT底物1抗体 Anti-PRAS40/AKT1 substrate 1 AKT1 substrate 1 （proline rich）; AKT1 substrate 1; AKT1-S1; AKT1S-1; AKT1S1; Lobe; PRAS 40的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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