蛋白激酶B2Anti-AKT2C AKT; MGC9965; Oncogene AKT1; PKB; PRKBA; Protein Kinase B Alpha; RAC Alpha; RAC; RAC PK
360TIYO.COM-上海田源公司

性能参数：

中文名称：蛋白激酶B2
英文名称：Anti-AKT2
别名：C AKT; MGC9965; Oncogene AKT1; PKB; PRKBA; Protein Kinase B Alpha; RAC Alpha; RAC; RAC PK
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent. [subcellular location] Cytoplasmic ａnd membrane-associated after cell stimulation leading to its translocation. In adult tissues, it is highly expressed in brain, lung ａnd kidney, but weakly in heart, testis ａnd liver. In fetal tissues, it is highly expressed in heart, liver ａnd brain ａnd not at all in kidney. Belongs to the Ser/Thr protein kinase family. RAC subfamily.Subcellular Location : Cytoplasm. Nucleus. Cell membrane （By similarity）. Note=Nucleus after activation by integrin-linked protein kinase 1 （ILK1） （By similarity）. Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 ａnd Ser-473 leading to its activation ａnd the activated form translocates to the nucleus.Tissue Specificity : Widely expressed. Low levels found in liver with slightly higher levels present in thymus ａnd testis.Similarity : Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 PH domain.Contains 1 protein kinase domain.Subunit : Interacts （via PH domain） with TCL1A; this enhances AKT3 phosphorylation ａnd activation. Interacts with TRAF6.激酶和磷酸酶（Kinases ａnd Phosphatases）Murine thymoma viral（v-akt） oncogene homolog-2（AKT-2;PRKBB）—蛋白激酶AKT-2，被认为也是原癌基因。受PDGF，EGF，FGF激活，经过phosphatidylinositol 3-kinase作用而活化。通过对凋亡调控蛋白的磷酸化而灭活其活性，抑制细胞的凋亡.

蛋白激酶B2的质量标准：

■其它名称：	C AKT; MGC9965; Oncogene AKT1; PKB; PRKBA; Protein Kinase B Alpha; RAC Alpha; RAC; RAC PK
■交叉反应：	hu, mo, rat
■产品类型：	一抗
■应用领域:	/肿瘤/细胞生物/免疫学/神经生物学/信号转导/细胞凋亡/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 56kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human AKT2 C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//Flow-Cyt=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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由于化学产品的特殊性，恕不接受以下投诉：
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蛋白激酶B2Anti-AKT2的相关产品目录：







1mg/1ml 蛋白激酶B2 Anti-AKT2 C AKT; MGC9965; Oncogene AKT1; PKB; PRKBA; Protein Kinase B Alpha; RAC Alpha; RAC; RAC PK 的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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