蛋白激酶B3Anti-AKT3AKT3 kinase; DKFZP434N0250; PKB Gamma; PKBG; PRKBG; Protein Kinase AKT3; Protein Kinase B
360TIYO.COM-上海田源公司

性能参数：

中文名称：蛋白激酶B3
英文名称：Anti-AKT3
别名：AKT3 kinase; DKFZP434N0250; PKB Gamma; PKBG; PRKBG; Protein Kinase AKT3; Protein Kinase B
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Akt, protein kinase B （PKB）, is a serine/threonine kinase which is involved in many cellular signaling pathways ａnd acts as a transducer of many functions initiated by growth factor receptors that activate phosphtidylinositol 3 kinase （PI 3 kinase）. The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI3 kinase ａnd Akt/PKB kinase activity. There are 3 known isoforms of this enzyme in mammalian cells （1/alpha, 2/beta ａnd 3/gamma）. IGF1 leads to the activation of AKT3, which may play a role in regulating cell survival. It is capable of phosphorylating several known proteins.Subcellular Location : Cytoplasm. Nucleus. Cell membrane （By similarity）. Note=Nucleus after activation by integrin-linked protein kinase 1 （ILK1） （By similarity）. Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 ａnd Ser-473 leading to its activation ａnd the activated form translocates to the nucleus.Tissue Specificity : Widely expressed. Low levels found in liver with slightly higher levels present in thymus ａnd testis.Similarity : Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 PH domain.Contains 1 protein kinase domain.Subunit : Interacts （via PH domain） with TCL1A; this enhances AKT3 phosphorylation ａnd activation. Interacts with TRAF6.

蛋白激酶B3的质量标准：

■其它名称：	AKT3 kinase; DKFZP434N0250; PKB Gamma; PKBG; PRKBG; Protein Kinase AKT3; Protein Kinase B
■交叉反应：	hu, mo, rat, shp, pig, dog, chk, cow, Rb
■产品类型：	一抗
■应用领域:	/肿瘤/免疫学/信号转导/转录调节因子/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 56kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human AKT3
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:200-600//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//Flow-Cyt=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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质量投诉流程
1、向我们的客户服务部反应投诉原因及订单信息。
2、向我们发送投诉相关的证明材料。
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友情提醒：
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
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蛋白激酶B3Anti-AKT3的相关产品目录：







1mg/1ml 蛋白激酶B3 Anti-AKT3 AKT3 kinase; DKFZP434N0250; PKB Gamma; PKBG; PRKBG; Protein Kinase AKT3; Protein Kinase B 的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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