磷酸化p21激活激酶1/2/3抗体Anti-phosphor-PAK1+PAK2+PAK3 （Ser141）PAKalpha; serine/threonine-protein kinase PAK 1; p21 activated kinase 1; PAK alpha; Paka;
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性能参数：

中文名称：磷酸化p21激活激酶1/2/3抗体
英文名称：Anti-phosphor-PAK1+PAK2+PAK3 （Ser141）
别名：PAKalpha; serine/threonine-protein kinase PAK 1; p21 activated kinase 1; PAK alpha; Paka;
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：In mammals, there are several identified isoforms of p21 Activated Protein Kinases or PAKs: PAK1 ａnd PAK3 are mostly brain specific, while PAK2 is expressed ubiquitously. Mutations of the gene coding for PAK3 are associated with X linked mental retardation ａnd PAK3 is a key regulator of synapse formation ａnd plasticity in the hippocampus. PAK3 is thought to play a key role in regulation of cell shape ａnd motility as well as cell death. P21-activated kinase （PAK） is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, ａnd PAK 3 （also known as alpha PAK, gamma PAK, ａnd beta PAK, respectively）. These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 （SH3） domains, ａnd caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 （serine 144 for PAK 1 ａnd serine 139 PAK 3）, catalyzed by Cdc42, is required for activation of PAK.PAK1-3蛋白具有广泛的生物学功能,也是一个保守的丝氨酸/苏氨酸蛋白激酶,参与许多重要的细胞活动。包括细胞骨架的动力学调节,细胞移动,生存和凋亡,细胞周期,基因转录调节,细胞生长信号转导和转化等。

磷酸化p21激活激酶1/2/3抗体的质量标准：

■其它名称：	PAKalpha; serine/threonine-protein kinase PAK 1; p21 activated kinase 1; PAK alpha; Paka;
■交叉反应：	hu, mo, rat, cow, Rb, hrs, dog
■产品类型：	一抗磷酸化抗体
■应用领域:	/肿瘤/细胞生物/信号转导/细胞凋亡/转录调节因子/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 60kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human PAK1 around the phosphorylation site of （Ser141）
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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由于化学产品的特殊性，恕不接受以下投诉：
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磷酸化p21激活激酶1/2/3抗体Anti-phosphor-PAK1+PAK2+PAK3 （Ser141）的相关产品目录：







1mg/1ml 磷酸化p21激活激酶1/2/3抗体 Anti-phosphor-PAK1+PAK2+PAK3 （Ser141） PAKalpha; serine/threonine-protein kinase PAK 1; p21 activated kinase 1; PAK alpha; Paka; 的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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