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肿瘤血管内皮标志物8抗体 田源一抗
点击次数:139发布时间:2012/8/14 10:11:38
更新日期:2013/6/26 15:58:38
所 在 地:其它
产品型号:Anti-ANTXR1/TEM8
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详细内容
肿瘤血管内皮标志物8抗体Anti-ANTXR1/TEM8Anthrax toxin receptor 1; Anthrax toxin receptor 1 precursor; ANTXR 1; ANTXR1; ATR; TEM-8;
360TIYO.COM-上海田源公司
性能参数:
中文名称:肿瘤血管内皮标志物8抗体
英文名称:Anti-ANTXR1/TEM8
别名:Anthrax toxin receptor 1; Anthrax toxin receptor 1 precursor; ANTXR 1; ANTXR1; ATR; TEM-8;
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:TEM8 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has also been shown to be a docking protein or receptor for Bacillus anthracistoxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor(EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.Subcellular Location : Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein.Tissue Specificity : Detected in umbilical vein endothelial cells. Highly expressed in tumor endothelial cells.Similarity : Belongs to the ATR family.Contains 1 VWFA domain.Subunit : Interacts with gelatin and type 1 collagen. Interacts with the actin cytoskeleton. Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium.肿瘤血管内皮标志物8是I型跨膜蛋白,是一种肿瘤特异性血管内皮标记蛋白。肿瘤血管内皮标志物8抗体的质量标准:
■其它名称: | Anthrax toxin receptor 1; Anthrax toxin receptor 1 precursor; ANTXR 1; ANTXR1; ATR; TEM-8; |
■交叉反应: | hu, mo, rat, Rb, pig, dog |
■产品类型: | 一抗 |
■应用领域: | /肿瘤/免疫学/血管内皮细胞 |
■蛋白分子: | predicted molecular weight: 44kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human ANTXR1 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//Flow-Cyt=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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肿瘤血管内皮标志物8抗体Anti-ANTXR1/TEM8的相关产品目录:
1mg/1ml 肿瘤血管内皮标志物8抗体 Anti-ANTXR1/TEM8 Anthrax toxin receptor 1; Anthrax toxin receptor 1 precursor; ANTXR 1; ANTXR1; ATR; TEM-8;的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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