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磷酸化微管相关蛋白抗体 田源一抗磷酸化抗体
点击次数:106发布时间:2012/8/14 10:12:56
更新日期:2013/6/6 11:01:19
所 在 地:其它
产品型号:Anti-phospho-Tau protein(Ser199)
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详细内容
磷酸化微管相关蛋白抗体Anti-phospho-Tau protein(Ser199)MAPT(phospho S199);DDPAC; Disinhibition dementia parkinsonism amyotrophy complex; FTDP 17;
360TIYO.COM-上海田源公司
性能参数:
中文名称:磷酸化微管相关蛋白抗体
英文名称:Anti-phospho-Tau protein(Ser199)
别名:MAPT(phospho S199);DDPAC; Disinhibition dementia parkinsonism amyotrophy complex; FTDP 17;
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.P-tau蛋白是脑内神经元细胞支架蛋白.其正常功能是促进微管蛋白组成微管,并维持已形成微管的稳定性.参与维持细胞形态、信息传递、细胞分裂等重要生物学过程,是轴突生长发育和神经元极性形成的不可缺少因素. 近年来发现tau蛋白与一些中枢神经系统变性疾病密切相关,尤其是神经Tau具有启动微管系统的装配以及稳定微管系统的作用,该蛋白的错误折叠与老年性痴呆等神经退行性疾病密切相关.磷酸化微管相关蛋白抗体的质量标准:
■其它名称: | MAPT(phospho S199);DDPAC; Disinhibition dementia parkinsonism amyotrophy complex; FTDP 17; |
■交叉反应: | hu, mo, rat, dog, hrs, Rb |
■产品类型: | 一抗磷酸化抗体 |
■应用领域: | /免疫学/神经生物学/转录调节因子 |
■蛋白分子: | predicted molecular weight: 49kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated Synthesised phosphopeptide derived from human MAPT around the phosphorylation site of Ser199 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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磷酸化微管相关蛋白抗体Anti-phospho-Tau protein(Ser199)的相关产品目录:
1mg/1ml 磷酸化微管相关蛋白抗体 Anti-phospho-Tau protein(Ser199) MAPT(phospho S199);DDPAC; Disinhibition dementia parkinsonism amyotrophy complex; FTDP 17;的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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