产品展示
线粒体促凋亡蛋白抗体 田源一抗
点击次数:123发布时间:2012/8/14 10:13:11
更新日期:2013/6/26 15:52:53
所 在 地:其它
产品型号:Anti-Smac/DIABLO
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详细内容
线粒体促凋亡蛋白抗体Anti-Smac/DIABLOBSP 1; BSP1; Smac / Diablo;Dwarfin A; DwfA; hSMAD 1; hSMAD1; JV 41; JV4 1; JV41; MAD mothe
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性能参数:
中文名称:线粒体促凋亡蛋白抗体
英文名称:Anti-Smac/DIABLO
别名:BSP 1; BSP1; Smac / Diablo;Dwarfin A; DwfA; hSMAD 1; hSMAD1; JV 41; JV4 1; JV41; MAD mothe
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively. The inhibitor of apoptosis (IAP) proteins regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes their inhibitory effect on caspases has been designated Smac/DIABLO. This is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates the cytochrome c/Apaf-1/caspase-9 pathway. Analysis of the structural basis of Smac/DIABLO reveals that the N-terminal amino acids are required for binding of Smac/DIABLO to IAPs and activation of caspases. Smac/DIABLO is expressed in a variety of human and mouse tissues.Smac(second mitochondria-derived activator of caspase)又称DIABLO(direct IAP binding protein),是一种线粒体蛋白,也是重要的促细胞凋亡蛋白,能够促进细胞凋亡,当杀死不正常细胞的机制启动后,线粒体释放出Smac蛋白促使受损或不正常细胞凋亡的生化过程就会出现,Smac在诱导肿瘤细胞凋亡,增加肿瘤细胞的化疗敏感性及增强免疫力等方面有一定的意义和应用前景。Smac是第二个线粒体来源的胱氨酸酶激活剂,它通过拮抗或中和一种或几种凋亡抑制蛋白(IAP)家族成员而发挥其促凋亡作用。线粒体促凋亡蛋白抗体的质量标准:
■其它名称: | BSP 1; BSP1; Smac / Diablo;Dwarfin A; DwfA; hSMAD 1; hSMAD1; JV 41; JV4 1; JV41; MAD mothe |
■交叉反应: | hu, mo, rat, dog, pig, cow, hrs, chk |
■产品类型: | 一抗 |
■应用领域: | /肿瘤/细胞生物/信号转导/细胞凋亡/激酶和磷酸酶 |
■蛋白分子: | predicted molecular weight: 27kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human Smac C-terminus |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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线粒体促凋亡蛋白抗体Anti-Smac/DIABLO的相关产品目录:
1mg/1ml 线粒体促凋亡蛋白抗体 Anti-Smac/DIABLO BSP 1; BSP1; Smac / Diablo;Dwarfin A; DwfA; hSMAD 1; hSMAD1; JV 41; JV4 1; JV41; MAD mothe的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
查询其它抗体目录请点击本公司化工仪器网链接:http://www.chem17.com/st233816/erlist_675408.html
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