感觉神经性耳聋常染色体隐性遗传61抗体Anti-Slc26a5Prestin; Deafness neurosensory autosomal recessive 61; DFNB 61; DFNB61; MGC118886; MGC1188
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性能参数：

中文名称：感觉神经性耳聋常染色体隐性遗传61抗体
英文名称：Anti-Slc26a5
别名：Prestin; Deafness neurosensory autosomal recessive 61; DFNB 61; DFNB61; MGC118886; MGC1188
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：SLC26A5 （Solute carrier family 26, member 5） is specifically expressed in outer hair cells （OHCs） of the cochlea ａnd is essential in auditory processing. It acts as a motor protein that converts auditory stimuli to length changes in outer hair cells. It is a bidirectional voltage-to-force converter which uses cytoplasmic anions as extrinsic voltage sensors. The anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, ａnd towards the cytoplasmic side in response to depolarization. This translocation triggers conformational changes in the protein that alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane （short state）, ａnd increases when the ion has crossed the membrane to the outer surface （long state）. It acts as an incomplete transporter since it moves anions across the membrane, but does not allow the anions to dissociate ａnd escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the anion-binding site. Mutations in SLC26A5 have been associated with non-syndromic hearing loss.外毛细胞具有在高频声作用下改变其长度的能力,这使哺乳动物听觉器官表现出高敏感性及频率的分辨能力。Prestin是近来被识别的一种外毛细胞马达蛋白,它在外毛细胞高表达,而内毛细胞不表达,定位在外毛细胞的外膜上,已发现Prestin与外毛细胞的电运动性有密切关系.

感觉神经性耳聋常染色体隐性遗传61抗体的质量标准：

■其它名称：	Prestin; Deafness neurosensory autosomal recessive 61; DFNB 61; DFNB61; MGC118886; MGC1188
■交叉反应：	hu, mo, rat
■产品类型：	一抗
■应用领域:	/细胞生物
■蛋白分子：	predicted molecular weight: 82kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human Slc26a5 C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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感觉神经性耳聋常染色体隐性遗传61抗体Anti-Slc26a5的相关产品目录：







1mg/1ml 感觉神经性耳聋常染色体隐性遗传61抗体 Anti-Slc26a5 Prestin; Deafness neurosensory autosomal recessive 61; DFNB 61; DFNB61; MGC118886; MGC1188的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

查询其它抗体目录请点击本公司化工仪器网链接：http://www.chem17.com/st233816/erlist_675408.html

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